눈동자 색 변화에 영향을 미치는 요인

### 눈 색깔의 과학: 출생부터 성인기, 그리고 그 이후까지
* 👶 눈동자의 색은 태어날 때 완전히 발달하지 않으며, 생후 몇 달 동안 **홍채와 눈동자에 멜라닌 세포가 계속 채워져 눈이 어두워지는 경우**가 많습니다.
* 👴 쌍둥이 연구에 따르면 **백인 참가자의 10~15%가 6세에서 성인 사이에 눈이 어두워지는 것**으로 나타났으며, 눈 색깔은 성인이 되어서도 계속 변할 수 있습니다.
* 👁 노화와 관련된 변화는 눈동자 색에도 영향을 미칠 수 있으며, 노년층의 홍채 주위에 **하늘색 또는 회색 고리가 생기는 아커스 세닐리스**와 같은 질환은 눈동자 색에 영향을 줄 수 있습니다.
* - **호너 증후군, 푹스 이색 홍채염, 색소 분산 증후군 등 다양한 눈 질환**으로 인해 눈동자의 색이 변할 수 있습니다.
* 👓 녹내장 치료에 사용되는 프로스타글란딘을 포함한 약물은 눈 색깔 변화를 일으킬 수 있으며, 한 연구에 따르면 **12개월 후 환자의 5-23%가 라타노프로스트로 인해 눈이 어두워지는 것**으로 나타났습니다.
* 백반증과 같은 질병은 **홍채의 색소 손실**을 초래하는 멜라닌 세포의 자가 면역 파괴로 인해 **눈 색깔에 영향을 미칠 수 있습니다.**
* 🎭 감정 상태와 뇌의 외상도 일시적으로 눈동자의 색을 변화시킬 수 있으며, **공포는 더 급격한 동공 확장을 유발**하고 **뇌의 외상은 동공 크기에 영구적인 영향을 미칠 수 있습니다.**
* 👁 선천성 무홍채증 환자를 위한 홍채 임플란트와 같은 의료 기술의 발전은 **개인이 자신의 눈 색깔을 선택할 수 있는 가능성**을 제공하지만, 이러한 시술은 아직 비교적 새롭고 잠재적인 위험을 수반합니다.

눈동자 색은 유전, 노화, 질병, 약물, 감정 상태 등 다양한 요인으로 인해 변할 수 있습니다.

You probably think you know the 
color of your eyes pretty well. After all, most of us see them staring 
back at us in the mirror every day. And while our bodies may 
change, eye color is permanent. Until it’s not. There are a shocking number of things that 
can make your baby blues not so blue anymore, or can make your brown-eyed 
girl need a new nickname. Here are just a few of them. First, let’s start by breaking 
down how the iris works. Your iris is the gatekeeper 
to light entering the eye. It contains the muscle to open and close the pupil 
so it regulates how much light gets in there. Irises also come in a 
spectrum of spectacular colors thanks to their cellular makeup. There are two layers of the iris. Within these layers, there’s a whole bunch of very important stuff that all helps you see. But the bits we want to focus on are the ones that have to do with eye color.

the melanocytes. Melanocytes are found in both layers of the iris. Two-thirds of all cells in the anterior layer, which is called the iris stroma, are melanocytes. So this layer is doing a lot of heavy lifting in giving your eyes their hue. And melanocytes aren’t just in your eyes. They make melanin all throughout your body. This is the same melanin that gives your skin and hair whatever color they’ve got. Melanin absorbs light, meaning it can’t be reflected back to be perceived by us. More melanin in a spot means more light is being absorbed there, and we see it as a darker color. So in brown eyes, there’s lots of melanin present and lots of light being absorbed. But lighter-colored eyes have less melanin, which means that the shorter wavelengths of light get reflected back off of collagen fibers. And then when someone else looks at those melanin-lacking eyes, their eyes pick up on that reflected light.

and that is how we see each other’s eye color. Melanin also comes in two forms: eumelanin, which is black or dark brown, and pheomelanin, which is light brown, yellow, or red. And different combinations of eumelanin and pheomelanin will affect the color of your eyes, kind of like mixing paint colors. For example, people with green eyes have more of that yellow-red pheomelanin. But not all eye colors are the result of melanin. If you’ve got albinism or another condition where you have little to no melanin, it’s the blood vessels in the retina reflecting back light that give a pink or reddish hue. There’s also a lot that can change in a complicated system like the eyeball, so let us talk about a few ways your eye color can change! [ INTRO MUSIC ] Although babies spend about 9 months developing in the womb,

when they come into the 
world, all fresh and squishy, they are not done cooking just yet. And it’s not just growing 
bones and developing brains that change over the coming months and years. The eye color can change, too. Many babies have lighter eyes at 
birth than they will as adults. The idea is that melanocytes in those baby blues are either not finished moving into place, or the cells that are there haven’t gotten around to 
specializing as melanocytes yet. Over the first few months of life, the iris is populated with 
those pigment-making cells and gets darker. For the most part, the eye color will settle by around six years old. But for some, it doesn’t end there. A twin study found that 10-15% 
of white participants’ eyes continued to darken between age 6 and adulthood. The fact that this happens in twins shows a pretty strong link between age-changing eye color and genetics, so your darkening eyes might 
even run in the family.

But there’s a twist! Not only can growing to adulthood 
cause your eyes to get darker, aging all the way to your golden years can eventually make your eyes lighter. Kind of. Arcus senilis is a build up of lipids that can form around the iris and give it a light blue or gray ring. A sort of eyeball halo, if you will. This usually happens in elderly people, and the new hue is usually benign. But they can sometimes be a sign 
of another underlying condition. So it’s not a bad idea to get them checked out. There are also plenty of 
not-so-great eye conditions that can change your eye color. There are a few that can also lead to loss of pigment and lighter eyes. Horner’s syndrome is caused 
by damage or disruption to certain nerves in the head and neck. That comes with a whole bunch 
of neurological symptoms, but it also causes your eyes 
to get lighter in color. It’s super noticeable in babies, but in adults,

it can be harder to notice because it happens so slowly. You might only spot it when you look at a photo from 20 years ago and think, “hey, were my eyes like, way darker back then?” Likewise, Fuchs heterochromic iridocyclitis causes inflammation of structures in the front of the eye, including the iris. And eventually, all that inflammation comes with a lightening of the eyes. And are you proud of me for saying, “Fuchs heterochromic iridocyclitis” correctly? Because I am. It’s not fully understood what causes this to happen, but studies have found that people with Fuch’s have fewer melanocytes and smaller melanin producing machinery. And finally, we have pigment dispersion syndrome. The name basically just means a loss of pigment, which causes your eyes to get lighter. But it's the mechanism of this particular change where things get really interesting. Some researchers have proposed

that pigment loss happens with this condition because the iris is just too big for the eye, which causes it to bow backwards. This backward bowing causes the tiny thread-like fibers that hold the eye's lens in place to come into contact with the iris, which they are not supposed to do. And when that happens, those threads can literally rub the pigment off. It can also cause some other not-great things like glaucoma. But fortunately, glaucoma treatments can help treat pigment dispersion syndrome, too. Now instead of pigment gain or loss, the next one is kinda like DIY eye jewelry. Kayser-Fleischer rings are brown or grayish rings that can form a little ring around the iris. They’re caused by deposition of excess copper in the cornea, which lays over the top of the iris. These rings are common in patients with Wilson’s disease, a genetic disorder which causes an error in copper metabolism in the body, but they can also be caused by other problems like liver disease.

On the plus side, as long as you treat the condition that caused them to appear, Keyser-Fleischer rings should go away. Another bummer of a disease that can change eye color is cancer. Yes, iris melanomas are a thing. They’re not super common, but they do happen. Just like a skin melanoma, iris melanoma is a cancer starting in the melanocytes. And just as on the skin, this can present on the iris as dark brownish spots. They can also cause you to start seeing more floaters, and can change the shape of your pupil. Most iris melanomas will not be visible, but if new dark spots appear on your iris, it’s probably time to book an appointment with your doctor. And not only can a cancer cause your eye color to change, treating cancers can cause it too. There’s a rare type of eye cancer found in young children called retinoblastoma that is super aggressive.

But there’s a new treatment for retinoblastoma, which involves injecting chemotherapy drugs into the vitreous humor, which is the jelly-like substance between your lens and retina, of the affected eye. This sounds terrible, but like… we're getting the cancer. And while that treatment seems to work pretty well, there are a couple case studies that suggest the treatment also resulted in that eye getting lighter, giving those kids permanent heterochromia and a hell of a story to tell. We’ve got more cool science to share. But first, let me tell you about another way to learn cool science: Brilliant. With Brilliant, you don’t even need to limit yourself to science. You can choose from thousands of lessons in computer science and math too! All on one interactive learning platform. You can learn artificial intelligence with the help of professionals at Microsoft and Google. And you can harness some of the most advanced tools of our time, like large language models. With Brilliant

you can train models on real data 
and generate all kinds of products, like a poem or cover letter. And you can learn how the data your model trains on changes the product by comparing what comes from a model trained on Taylor Swift versus one trained on a cookbook. While you’re playing with those variables, you’ll build an understanding 
of large language models from the ground up. And since you learn this stuff 
through hands-on problem solving, you’re more likely to actually remember it. To get started, head to Brilliant.org/SciShow or the link in the description down below. That link also gives you 20% off an 
annual premium Brilliant subscription. And you’ll get your first 30 days for free! And thank you to Brilliant for 
supporting this SciShow video! Now we’ve talked about a lot of weird diseases that can change your eye color, but there are some medications 
that can do this too. One of the most common is a medication group

called prostaglandins, which are used to treat glaucoma. Glaucoma is just a blanket 
term for a group of conditions that cause increased pressure in your eye, and over time, damage to the optic nerve. And prostaglandins are great 
at lowering that pressure, so they are great for treating glaucoma. And they are also known for a weird side effect – darkening people’s irises. One study found that the 
glaucoma medication latanoprost caused between 5 to 23% of patients’ eyes to get darker after 12 months of treatment. It’s probably still a good idea to take these medications either way. Just don’t be surprised if 
you notice a new eye shade in your reflection afterwards. We’ve talked about dark flecks 
and white rings on the iris, but how about patchwork eye color? Vitiligo is an autoimmune disorder where your immune system turns on your melanocytes and destroys them.

It’s usually more apparent when 
it’s happening in the skin, since it causes large patches 
of skin to become much lighter than they were before. But it can happen to melanocytes in your eyes too, which can look like patchy blue spots in the iris, or more widespread loss of pigment. This specific presentation of vitiligo is often associated with 
specific eye-related syndromes like Vogt-Koyanagi-Harada syndrome and Alezzandrini's syndrome but can also happen in the more 
general, full-body vitiligo. And this is probably the most temporary eye color 
swapping method on our list – but your eye color can look really different depending on your emotional state. Novelists might be taking some artistic liberty when they describe eyes becoming 
“dark and stormy” in anger but there really is something there. Not all eye color changes come down to the iris. The size of the pupil plays a role too. Your pupil dilates differently

when you are processing different emotions. One study found that fear can cause the pupil to dilate more drastically than feelings of happiness or neutrality, which would temporarily make your eyes look a different color as less of your iris is visible. And of course this isn't really an eye color change, but it is the illusion of one. Another illusory eye color change can come from trauma to the brain or eye. A nasty knock on the head can cause your pupil to get permanently stuck at full dilation. And, like we mentioned before, greater pupil size equals less visible iris and a whole different looking eye color. This can happen in both eyes but usually it’s just one. And if this ever happens to you, you're in good company, since a permanently blown pupil was also the cause of David Bowie’s famous mismatched eyes. Whether it also makes you a rock legend… less clear. Everything we’ve talked about so far that can change your eye color comes down mostly to a roll of the dice.

But what if you could choose your own adventure and actually select your eye color? It sounds like science fiction, but for some, this has become a reality. Congenital aniridia is a rare genetic eye disorder where you are born without a part of or all of your iris. As with trauma to the eye, this means that your pupil is larger and your eyes look darker. Without the pupil control, this of course leaves people with sensitivity to light and even lead to vision loss. But there’s a procedure that can help correct this - an iris implant! They are not FDA approved yet, but doctors can get exemptions to use them on compassionate grounds in the US, and they are available in some other countries. And the caution to approve them for wider scale use might be warranted. Because although iris implants might improve vision and reduce glare in individuals with aniridia, they might also cause some nasty complications like glaucoma. These prostheses are still pretty new.

so it’s up to each individual and their doctor to weigh the risks and benefits. So if you do have a condition where having a new iris could 
really help, technically, you could go for any color you want. Maybe throw some stripes on 
there and get funky with it. So now you know! There’s a lot that can happen 
to change your eye color. And while it may be jarring to see such a change, no matter what color they are, we think that beauty is in 
the eyes of the beholder. [outro]

11 Things That Can Change Your Eye Color

SciShow explores the unexpected. We delve into the scientific subjects that defy our expectations and make us even more curious! 

For more from SciShow, check out SciShow Kids and SciShow Tangents, along with SciShow Space and Psych.


SciShow

눈동자의 색은 홍채의 멜라닌 양에 따라 결정되며, 멜라닌이 많으면 눈이 더 어두워지고 멜라닌이 적으면 눈이 더 밝아집니다.

홍채의 유멜라닌과 페오멜라닌의 조합은 물감을 섞는 것과 비슷하게 다양한 눈동자 색을 만들 수 있습니다.

어떤 경우에는 망막의 혈관이 분홍색 또는 붉은 색조를 띠는 알비니즘과 같은 질환의 영향을 받아 눈 색깔이 달라질 수도 있습니다.

눈동자 색은 출생부터 성인이 될 때까지 크게 변할 수 있으며, 생후 몇 개월 동안 홍채가 더 어두워질 수 있습니다.

유전적 요인은 눈 색깔의 진화에 큰 역할을 하며, 성인이 되어서도 계속 어두워지고 노년기에는 밝아질 수 있습니다.

특정 눈 질환 및 증후군으로 인해 눈의 색이 밝아질 수도 있으며, 이는 근본적인 건강 문제와 색소 손실을 나타냅니다.

눈의 색소 손실은 색소 분산 증후군으로 인해 발생할 수 있으며 녹내장으로 이어질 수도 있지만 녹내장 치료제로 치료할 수 있습니다.

각막에 과도한 구리 침착으로 인해 발생하는 카이저-플라이어 고리는 윌슨병 환자에게 흔히 발생하며 기저 질환을 치료하면 해결할 수 있습니다.

홍채 흑색종은 드물지만 홍채에 검은 반점과 시력 변화를 일으킬 수 있으므로 새로운 반점이 나타나면 의사의 진찰을 받아야 합니다.

어린이에게 발생하는 희귀 안암인 망막모세포종은 화학 요법으로 치료할 수 있으며, 이 경우 감염된 눈에 영구적인 이색증을 유발하는 것으로 알려져 있습니다.

다양한 데이터가 모델 학습에 미치는 영향

테일러 스위프트의 가사나 요리책과 같은 다양한 유형의 데이터로 모델을 학습시키면 다양한 결과물을 얻을 수 있어 대규모 언어 모델을 이해하는 데 도움이 됩니다.

org는 연간 프리미엄 구독 시 20% 할인을 제공하며, 첫 30일은 무료입니다.

녹내장 치료제는 눈 색깔에 변화를 일으킬 수 있으며, 백반증도 멜라닌 세포를 파괴하여 눈 색깔에 영향을 줄 수 있습니다.

또한 감정 상태와 동공 크기도 일시적으로 눈동자의 색을 변화시킬 수 있습니다.

두려움은 동공을 확장시켜 다른 눈동자 색으로 착각하게 만들 수 있으며, 외상은 동공 확장으로 인해 눈동자 색을 영구적으로 변화시킬 수 있습니다.

선천성 무홍채증 환자에게는 홍채 임플란트 시술을 통해 눈동자 색을 선택할 수 있지만 녹내장과 같은 합병증의 위험이 따릅니다.