콜레스테롤이 뇌 건강에 미치는 영향

높은 콜레스테롤은 뇌 기능과 인지 건강에 매우 중요합니다.

### 콜레스테롤이 뇌 건강에 미치는 영향과 저지방 식단의 위험성
* 🧠 콜레스테롤은 신경 세포막과 신경 전달 물질의 구조를 지원하여 뇌 기능에 중요한 역할을 하므로 **콜레스테롤 수치가 낮으면 전반적인 뇌 기능이 저하**될 수 있습니다.
* 🧠 70세 이상의 노인 인구에서 **콜레스테롤 수치가 높을수록 치매 위험이 감소**하는 것으로 알려져 있습니다.
* 🚶 ↪f_200D↩♀️ **총 콜레스테롤 수치가 여성 201, 남성 200 미만**이면 기능 능력과 인지 장애의 위험이 크게 증가합니다.
* 🧠 콜레스테롤 저하제인 **로수바스타틴은 인지 기능에 부정적인 영향**을 미치는 것으로 나타났습니다.
* 🍽 고지방 식단은 알츠하이머 및 인지 장애의 위험 감소와 관련된 **HDL 수치를 증가**시킬 수 있습니다.
* 💔 포화 지방은 **LDL을 증가**시킬 수 있지만, 중성 지방은 감소하고 **HDL은 증가**하여 심혈관 건강을 개선하고 당뇨병과 고혈압의 위험을 감소시킵니다.
* 심장마비와 같은 급성 심혈관 질환의 경우 **LDL 수치는 신뢰할 수 있는 예측 인자가 아니며**, 중성지방과 HDL의 비율이 임상적으로 더 중요한 지표입니다.
* 주로 동물성 식품에 함유된 **비타민 B1을 적절히 유지**하는 것은 뇌 건강과 뇌 위축을 예방하는 데 매우 중요합니다.

Have you watched Episode 123 well because it contains very important content? For those who haven't seen it, please watch Episodes 1, 2, and 3 first. In Episode 1, we introduced a study on blood cholesterol levels and cognitive function in the Scottish Lothian region. When looking at the data, an overall pattern emerged. Why does overall brain function decrease when cholesterol levels are low? This image shows the cell membrane of a nerve cell. Here, there is a structure called a lipid raft, and the yellow part in between is cholesterol. Cholesterol not only prevents the lipid raft from spreading but also functions as an adhesive. Neurotransmitters essential for brain function such as acetylcholine, dopamine, and serotonin rely on this lipid raft to function properly. In other words, cholesterol is truly essential for brain function.

Cholesterol accounts for 25% of the cholesterol in the brain, even though the brain comprises only 2% of body weight. This means that the brain requires significantly more cholesterol, about 13 times more than other organs. A deficiency in cholesterol can lead to cognitive function decline, which is a natural consequence. In extreme cases, it may even lead to brain failure. This study focuses on the effects of statin use on cognitive function. The group using statins showed a significant decrease in overall cognitive function, as well as processing speed and memory. It is a natural consequence of decreased cholesterol due to statin use. Another study investigates the risk of dementia in the elderly population aged 70 to 79 with high total cholesterol levels. Data shows that as cholesterol levels increase in the 70s, the risk of dementia decreases by 23%.

The risk of occurrence decreased by more than three times compared to the group. At the age of 75, the risk of dementia decreased, and in the group with the highest cholesterol, the risk decreased by as much as five times. The same pattern was observed at the age of 79. In other words, in the elderly over 70 years old, as cholesterol levels increase, the risk of severe occurrence decreases. This time, we investigated total cholesterol and functional ability between the ages of 55 and 85. We examined getting up from a chair, walking 3 meters, putting on a cardigan, and looking at a book. In women, with total cholesterol below 201, performance ability and risk of occurrence increased by 2.5 times, and in men, it also increased by 3 times. Do you need to excessively lower your total cholesterol below 200? This time, we also studied the relationship between blood cholesterol levels and the risk of Parkinson's disease. Looking at the data, as the total cholesterol levels increase,

The risk of developing Parkinson's disease has significantly decreased. The decrease effect was observed for total cholesterol levels of 228 and above. Particularly in the elderly, if cholesterol is greatly reduced, there is a high possibility of serious brain function problems occurring. I am shocked and amazed by the fact that there are still societies recommending low-fat meals that remove all fats to lower cholesterol. To lower cholesterol, should we eat bean oil, corn oil, margarine instead of butter? Should we consume low-fat milk or skim milk instead of whole milk? Will you continue to recommend rice cakes and cereal as good foods, and say that noodles and cold noodles are good foods because they are low in fat? Will you not update the website? This time, let's look at the Framingham Heart Study. According to the data, as cholesterol levels increase, verbal fluency decreases.

It improves a lot. Learning and memory are better when cholesterol levels are higher. Concentration also significantly improves as cholesterol increases. Overall cognitive performance showed the same pattern. Researchers recommend a total cholesterol level of 200 or below, but in the group with levels below 200, overall cognitive function and performance were significantly impaired. On average, people who are unique, articulate, and intelligent often have high cholesterol. Now let's talk about the impact of Rosuvastatin on cognitive function. In terms of concentration, the group receiving Rosuvastatin performed much worse. In almost all cognitive functions such as mental processing speed, mental flexibility, working memory, and memory recall, the group taking the medication performed much worse compared to the control group that did not take the medication. Just a moment ago, it was similar to a Russian study.

Patterns, it's a matter of overall cognitive function. It's natural. Should we still expect salvation from statins while eating non-greasy rice cakes? Is a low-fat diet really a healthy diet? Low-fat diets were proven to be meaningless back in 2006. In order to confirm whether a low-fat diet reduces the risk of chronic diseases, a research of the largest scale ever, with a budget of 500 billion, was conducted. The results showed that a low-fat diet has no effect on preventing chronic diseases such as breast cancer, colon cancer, heart failure, and stroke. At that time, the atmosphere was like this. The negative results from this study were unexpectedly and disappointingly received by the nutrition community. Researchers clearly expressed their unwillingness to believe the results that a low-fat diet does not prevent breast cancer, colon cancer, and heart disease. Why would they not want to believe it?

Do you do comedy? Just believe it. Since the announcement of the low-fat dietary guidelines in 1977, ignoring numerous objections, we have been living in the era of low-fat. In this process, diabetes has been explosively increasing. Should we continue the low-fat diet? Consuming saturated fats increases LDL, but neutral fats, one of the root causes of chronic diseases such as obesity, diabetes, and hypertension, decrease, and HDL increases. Especially, when following a low-carb high-fat diet, this pattern is more clearly visible. As the neutral fat to HDL ratio decreases, the risk of cardiovascular disease also decreases. As insulin levels decrease, the risk of diabetes and hypertension also decreases. As visceral fat decreases, the risk of metabolic syndrome, the root cause of many diseases, also decreases. In other words, it means that blood vessels can become healthier. In this study, with a high-fat diet,

I compared low-fat meals. In the high-fat group, the HTL level increased by 12 after 52 weeks, but there was almost no change in the low-fat meal group. In another study, in just 90 days of a high-fat diet, HDL increased by about 12. Eating a high-fat diet like this will significantly increase the HTL level. What happens when the blood HTL level increases? This time, I studied HDL, Alzheimer's disease severity, in the normal group, the HDL level was 63.8, but in the Alzheimer's dementia group, it was 51.8, showing a significant difference. Cognitive function scores also showed an increasing trend as HTL increased. Will you follow a low-fat diet to prevent or treat dementia, or will you follow a high-fat diet? In other similar studies, the risk of dementia decreased by about 60% when the HTL level was above 55. Now, let's talk about LDL. When you have a high-fat diet, LDL increases. This time, let's talk about the LDL level.

We researched the risk ratio for dementia. The most critical factor for dementia was when LDL was below 112, and as the LDL levels increased, the risk decreased significantly. Researchers stated that high LDL levels are associated with a decrease in dementia occurrence and have a potential protective effect against cognitive impairment. Similar studies have confirmed that in groups with high total cholesterol and HDL cholesterol, the risk of cognitive impairment is significantly reduced by 27%, 19%, and 19%, respectively. This time, we compared mild cognitive impairment and normal individuals in the pre-dementia stage. The average total cholesterol was 192 in the normal cognition group and 177 in the mild cognitive impairment group. HDL cholesterol showed a difference between the normal group at 53.8 and the mild cognitive impairment group at 52.6. LDL cholesterol exhibited a significant difference between the normal group at 111 and the mild cognitive impairment group at 103. In other words, low total cholesterol levels and low HDL cholesterol levels were associated with a higher risk of cognitive impairment.

The LDL and HDL levels showed a significant association with mild cognitive impairment, a pre-stage of dementia. Let's look at a case of a rehospitalized patient who recently had a stroke. He is a 51-year-old man with no underlying conditions, does not drink alcohol or smoke. He was not taking any medications such as statins. Was his total cholesterol high? It was only 159, which is much lower than the national average of 190. This means he is 31 points below the average. Was his LDL cholesterol high? No, it was 89, significantly lower than the national average of 115, which is 26 points lower. Even though his total cholesterol and LDL are low, why does he have so many issues with his blood vessels? However, as I always mention, his triglycerides were very high at 292, and his LDL was only 38. This pattern of high triglycerides and low HDL is characteristic of cardiovascular disease patients. When the triglyceride to HDL ratio is above 4, it indicates a high-risk group for cardiovascular disease, which is the case for him.

With 7.7, which exceeds 4, this person falls into the category of very high risk for cardiovascular disease. Total cholesterol LDL is not the most important factor. It can be low or high in acute cardiovascular diseases like cerebral infarction, making it unpredictable. However, the ratio of neutral triglycerides to HDL is significantly different. Referring back to the study introduced in the previous segment, in acute coronary syndrome, meaning patients hospitalized for acute heart attacks, the LDL values were most frequently between 70 and 114. This implies that individuals with much lower LDL levels experienced acute heart attacks. In other words, LDL is a very poor indicator as a predictor of cardiovascular disease. In this study, the ratio of neutral triglycerides to HTL was 4.1. As mentioned, if it is above 4, it indicates a high risk of cardiovascular disease. Therefore, the ratio of neutral triglycerides to HTL is clinically much more important and effective. This time, we researched the levels of vitamin B19 and the degree of inflammation.

As the level of vitamin B1 increases, my atrophy decreased. To maintain brain size, vitamin B1 is crucial. Vitamin B1 is mainly found in animal products such as eggs, fish, and meat. Having treated dementia patients for over 20 years professionally, I firmly believe that those who regularly consume healthy fats like eggs, fish, and meat are less likely to develop dementia. Sufficient intake of healthy fats helps maintain cholesterol levels necessary for brain function and enables the maintenance of a healthy brain size with adequate intake of vitamin B1. Will you choose a low-fat diet or a high-fat diet for brain health? Conversely, continuing a low-fat diet reduces LDL but also decreases HDL, while increasing triglycerides. In other words, the issue arises when triglycerides increase while the HDL ratio increases.

The risk of cardiovascular disease also increases, and as the insulin levels in the blood rise, the risk of developing diabetes and hypertension also increases. With the increase of visceral fat, the risk of metabolic syndrome also increases. In other words, it means that vascular health can deteriorate. When summarizing the contents from part 1 to this part 4, it can be judged that a low-fat diet may actually increase the risk of chronic diseases such as diabetes, hypertension, metabolic syndrome, Parkinson's disease, and sales, and it is likely to increase the overall mortality rate. Despite the fact that excessive carbohydrate intake is much more harmful to heart health than cholesterol, it is frustrating and worrisome to see people still insisting on a low-fat diet. The fact that fat and cholesterol are harmful is far past its expiration date.

This is an old hypothesis. If you insist on clinging to such outdated hypotheses, many people will lose their health. It is essential to recognize the fact that lowering LDL excessively can impair brain function and increase the risk of dementia. We will see you again in Health Deal Episode 5. Then, Doctor 3 will come back with even better videos next time. If you enjoyed my video, please press like and subscribe. Doctor 3 supports your health.

"이것" 부족해지면 뇌신경이 파괴됩니다 [LDL 4편] 난 니가 콜레스테롤에 한짓을 알고있다

안녕하세요. 신경외과 전문의 닥터쓰리입니다. 제 채널에서는 평소에 누구나 궁금해하는 의학 상식과 병원에서는 절대 들을 수 없는 진짜 의료정보, 그리고 잘못된 의학상식을 바로 잡는 가이드 역할을 충실히 하겠습니다

닥터쓰리 - 한미일의사의 쉬운 의학

뇌 기능에서 콜레스테롤의 중요한 역할

콜레스테롤은 신경전달물질과 세포막의 기능에 필수적이기 때문에 낮은 콜레스테롤 수치는 뇌 기능 저하와 관련이 있습니다.

콜레스테롤을 낮추는 스타틴의 사용은 인지 기능 저하와 관련이 있습니다.

노인 인구에서 콜레스테롤 수치가 높으면 치매 위험이 감소하는 것과 관련이 있습니다.

또한, 지나치게 낮은 콜레스테롤 수치는 남성과 여성 모두의 기능적 능력에 부정적인 영향을 미칠 수 있습니다.

콜레스테롤 수치와 저지방 식단이 파킨슨병과 인지 기능에 미치는 영향

콜레스테롤 수치가 228 이상이면 파킨슨병의 위험이 감소하는 것으로 알려져 있습니다.

특히 노인의 경우 콜레스테롤을 줄이면 심각한 뇌 기능 문제를 일으킬 수 있습니다.

프래밍햄 심장 연구와 로수바스타틴의 영향 모두 저지방 식단에 대한 일반적인 권장 사항에도 불구하고 높은 콜레스테롤 수치가 인지 기능 향상과 관련이 있음을 시사합니다.

고지방 식단이 건강에 미치는 영향

고지방 식단은 HDL 수치를 높이고 당뇨병, 고혈압, 대사 증후군의 위험을 낮추는 등 심혈관 건강에 잠재적인 이점을 제공합니다.

또한, HDL 및 LDL 수치가 높을수록 인지 장애의 위험이 감소하기 때문에 이러한 식단은 치매를 예방하는 효과도 있을 수 있습니다.

반면 저지방 식단은 당뇨병 증가와 관련이 있으며 치매에 대한 보호 효과가 적습니다.

고지방 식단과 저지방 식단을 비교한 결과, 고지방 식단이 HDL 수치에 긍정적인 영향을 미치는 것으로 일관되게 나타났습니다.

콜레스테롤 수치가 인지 건강 및 심혈관 질환에 미치는 영향

콜레스테롤 수치, 특히 중성지방 대 HDL 비율은 총 콜레스테롤이나 LDL 수치보다 심혈관 질환 위험을 더 잘 나타냅니다.

트리글리세리드 대 HDL 비율이 높으면 심혈관 질환 위험이 매우 높습니다.

LDL 수치가 낮다고 해서 반드시 급성 심혈관 질환의 위험이 낮은 것은 아닙니다.

비타민 B1이 풍부한 건강한 지방을 섭취하는 것은 뇌 건강을 유지하고 치매를 예방하는 데 매우 중요합니다.

저지방 식단의 위험과 건강한 지방의 중요성

저지방 식단은 실제로 심혈관 질환, 당뇨병, 고혈압 및 대사 증후군의 위험을 증가시킬 수 있습니다.

과도한 탄수화물 섭취는 콜레스테롤보다 심장 건강에 더 해롭습니다.

LDL을 과도하게 낮추면 뇌 기능이 손상되고 치매 위험이 높아질 수 있습니다.