아르기닌: 아르기닌의 효과, 위험성 및 암에 대한 우려

근육 형성을 위해 아르기닌을 섭취하는 것은 안전하지만, 암 환자는 아르기닌의 잠재적인 mTOR 단백질 활성화로 인해 아르기닌 섭취를 피해야 합니다.

### 아르기닌: 효과, 우려 사항 및 권장 사항
* 💪 아르기닌은 **혈관을 이완**하고 혈액 순환을 촉진하며 **혈압을 낮추고 소화**를 돕습니다. 또한 **근육 합성을 촉진**하여 운동 전에 섭취하면 운동에 도움이 됩니다.
* 🚫 치료 중이거나 치료 중 휴식을 취하는 암 환자와 같이 간에 문제가 있는 사람은 아르기닌이 **mTOR 단백질에 미치는 영향** 때문에 **아르기닌 섭취에 주의**해야 합니다.
* 🎯 mTOR는 에너지가 과도할 때 작동하는 단백질로, **더 많은 단백질과 지방을 합성**하고 몸을 정화하며 자가포식을 억제합니다.
* ⚖ 자가포식을 촉진하는 **AMPK**와 동화 작용을 촉진하는 **mTOR**가 서로 상호 작용할 때 균형을 유지하는 것이 중요합니다.
* 암 환자나 암 치료 중 휴식 중인 환자의 경우 **아르기닌은 세포 증식과 암을 유발할 수 있는 새로운 혈관 발달을 촉진**할 수 있으므로 섭취에 주의해야 합니다.
* 🔬 전임상 및 임상 데이터에 따르면 **폐암, 유방암, 난소암, 췌장암, 전립선암 및 기타 암과 관련된 잠재적 문제**가 있을 수 있습니다.
* ✅ 암 환자가 아닌 일반인의 경우, **아르기닌 섭취는 일반적으로 안전하고 유익**하며 특히 운동을 하는 사람들에게는 더욱 그렇습니다. 맹목적으로 mTOR를 억제하거나 아르기닌을 완전히 피하는 것은 권장되지 않습니다. **다른 영양소와 균형 있게 섭취하는 것이 중요**합니다.

I worked out so hard, so I should take arginine to build muscles, right? Hello, this is Yakdeulyak's pharmacist. Let's cheer first and get started. Fighting! Today's video is about arginine. Those who are like this, never take it. I will talk about those who should stop taking it immediately. Arginine is a very safe supplement with almost no side effects. However, there are people who should not take it. I will explain a bit deeper about why. First, let me briefly mention the general effects of arginine. Arginine relaxes blood vessels, promotes blood circulation, lowers blood pressure, and helps with digestion. It also promotes muscle synthesis, which helps with exercise when taken before working out.

If it is a supplement that can induce bulking up and also works in a cycle that detoxifies ammonia, the amino acid that functions in the liver is arginine. Generally known side effects may include gastrointestinal discomfort, mild allergies, and dizziness due to low blood pressure. Moreover, lysine deficiency-related shingles or inflammatory reactions may occur as absorption can lead to temporary elevation of liver enzymes. Therefore, I believe that individuals with liver issues, such as cancer patients undergoing treatment or taking a break during treatment, should be cautious when consuming arginine for vitality or energy enhancement purposes. The reason for this caution is mainly due to the metabolism of the mTOR protein.

When it comes to protein, what is m2? I briefly mentioned something called M-TOR when I was explaining about sirtuin saltwin before, and when I was explaining about autophagy, the process of cleaning our body, I mentioned M-TOR briefly. The factor that activates the M-TOR protein is arginine, that's right. Entor is the mechanistic target of rapamycin, the target substance of rapamycin. This means that m2 is the substance that rapamycin inhibits and was discovered. So, let's first find out what rapamycin is. In Korea, the prescription drug Synolis or Rapamenishi is prescribed, and this ingredient is used for immune suppression or anti-cancer purposes. It is an anti-cancer ingredient found in bacteria in the Eastern European soil.

In 1960, when it was first discovered and researched, it was found that the lifespan at the cellular level was extended. Furthermore, observing an extension of lifespan in mouse experiments made researchers wonder what exactly caused this substance to extend lifespan. Upon investigation, it was found that ultimately, this substance inhibits a protein called mTOR, which is involved in the process of rapamycin targeting. This substance is named mTOR. In the case of mTOR, when it is activated, we can infer that lifespan may be shortened, and diseases may develop. This is where the protein mTOR comes into play. Understanding a protein called m2 may be a bit difficult, so let me explain the opposite action more precisely with a protein I mentioned before, which is AMPK. When AMPK levels increase, mTOR levels decrease, and when mTOR levels increase, AMPK levels decrease, showing opposite actions towards each other.

APK is an enzyme that activates when our body lacks energy and the energy substance called AMP is high. So, when our body is in a state of low energy, that enzyme is activated. It works as an enzyme that prevents the breakdown of energy in our body, preventing the breakdown of proteins and fats. It promotes the production of energy by inhibiting the breakdown of energy due to the lack of energy. By burning energy, appetite increases, but as fat metabolism is stimulated, body fat decreases. As a result, autophagy is activated in our body, which can show anti-cancer and anti-inflammatory effects in the body, and by inducing consumption, it promotes the function of producing and metabolizing something in our body.

By synthesizing reproductive hormones, it promotes various metabolisms. Insulin resistance is reduced, blood pressure is lowered, and it has many beneficial effects. The enzyme that does this is called AMPK. The opposite of that is called mTOR. mTOR, on the contrary, operates when there is an excess of energy, when the stomach is full after eating a lot, or when there is little exercise. It is a protein that functions like this. mTOR, for example, stimulates digestion. When there is excess energy in our body, it synthesizes more proteins and fats. Also, due to the excess energy, it cleanses our body, suppresses autophagy, which prevents cancer, and reduces the organelles called lysosomes that break down within the cell. The organ that melts waste decreases, and as the muscles become stronger, cell replication increases a lot.

When it is converted into energy, a lot of this interaction occurs in the process, and it is known that if inflammation control is not well regulated during the process of cell production, cancer can be more likely to occur. It is known to be a bit more complicated in terms of signaling, but you can just think of it that way. When cells replicate a lot, if the inflammatory response is not well regulated and various antioxidant actions are not regulated, then the possibility of cancer occurrence increases. In fact, research is being conducted on an enzyme that blocks arginine as an anticancer treatment. There is data that about 20 something clinical trials are being conducted in phase 3 or higher. Blocking arginine to the extent that it can be used as an anticancer agent is now showing some beneficial effects on cancer patients. In summary, when the protein mTOR is activated, cell proliferation and the autophagy system are activated.

When suppressed, various inhibitions and somewhat fairy-tale-like stimulations can arise in the mind, leading to the possibility of developing emotions. In the case of cancer patients, one should be careful in that aspect. Activating a protein called mTOR is precisely what arginine does. It would be good to see it this way. Furthermore, arginine not only activates mTOR but also promotes the secretion and synthesis of nitric oxide, which expands blood vessels as mentioned earlier. It is said that when this happens, the newly formed blood vessels that can cause cancer can develop further. In cases of cancer, when arginine is not sufficient, cells with arginine-dependent deficiency may self-destruct. So, the probability of cancer occurrence decreases when there is enough arginine. Through these actions, arginine...

For cancer patients or those currently undergoing cancer treatment, and those on a break during their treatment, such as a leave of absence, it seems necessary to be cautious about consuming arginine. Particularly, based on the data I found, which mostly consists of preclinical cell experiments or animal experiments, there are data suggesting that various cancers such as lung cancer, breast cancer, ovarian cancer, and pancreatic cancer can mainly occur. Clinical trials show similar results, indicating potential issues related to prostate cancer, pancreatic cancer, and breast cancer. Therefore, it is advisable to be cautious. However, for those who are not cancer patients, there is absolutely no need to worry. Arginine is not necessarily bad. As I mentioned earlier, it is most important to maintain a balance between the protein AMPK, which promotes autophagy, and mTOR, which promotes anabolism, as they interact with each other. Therefore, blindly inhibiting mTOR is not necessary.

Not taking arginine blindly is not good. Therefore, it is not good to avoid consuming arginine altogether. So, consume it in balance. People who exercise like this, those who are not cancer patients, benefit a lot from consuming arginine, so there is no need to worry at all about consuming it. Especially, regarding concerns about cancer patients, it only applies to cancer patients. Therefore, saying that arginine is a big problem in causing cancer is really a speculation, and there is no data to support that. There are three substances that act as substrates activating protein with m2. The first is arginine, the second is glutamine, and the third is lysine. However, these substances create an anabolic effect and play a role in creating cells, but some people ask if consuming them can cause cancer or find it difficult.

Speculation and groundless claims, individuals who are not cancer patients, there is absolutely no data that consuming glutamine, lysine, or arginine causes cancer. So, don't worry, don't speculate too much, and keep this in mind as we strive for a healthier nutritional supplement lifestyle. Don't worry too much, I'm just mentioning this for your reference. Always, when cancer patients ask about arginine for their physical strength, I once mentioned it with care. Today's video talked about why people who consume arginine should not do so. If today's video was helpful, please like and subscribe. Thank you, bye. [MUSIC]

아르기닌 섭취 당장 중단하셔야 하는 분이 있습니다. (아르기닌을 섭취하면 안되는 이유, 부작용)

약국에서 설명 안해주는 약, 건강기능식품 및 의약외품 여러 용품에 대한 설명과 정보를 공유합니다 ^^

약사가 들려주는 약 이야기

아르기닌 보충제의 효과와 아르기닌 섭취를 피해야 하는 사람

아르기닌은 혈액 순환과 근육 합성을 촉진하는 등 다양한 효능이 있지만 위장 불편감이나 현기증과 같은 부작용을 일으킬 수 있습니다.

간 질환이 있는 사람, 특히 치료를 받고 있는 암 환자는 아르기닌이 mTOR 단백질과 간 효소에 영향을 미치기 때문에 아르기닌을 섭취할 때 주의를 기울여야 합니다.

mTOR 단백질과 관련된 라파마이신은 면역 억제 및 항암 목적으로 사용되는 처방약으로, 특정 개인에게 아르기닌의 잠재적 위험성을 더욱 강조합니다.

1960년에 발견되어 세포 수명을 연장하는 물질인 mTOR는 억제하면 수명 연장 및 질병 예방과 관련이 있습니다.

mTOR의 활성화는 수명을 단축하고 질병 발생과 관련이 있는 반면, 효소 AMPK는 에너지 생산과 신진대사를 촉진하는 반대 효과를 가지고 있습니다.

AMPK 활성화는 에너지 생산 증가, 체지방 감소, 자가포식 활성화로 이어져 항암 및 항염증 효과를 제공합니다.

신진대사와 세포 기능에서 AMPK와 mTOR의 역할

생식 호르몬을 합성하는 AMPK는 인슐린 저항성을 감소시키고 혈압을 낮추는 등 다양한 유익한 효과를 제공합니다.

반면에 mTOR는 에너지가 과잉 공급될 때 작동하여 소화를 촉진하고 단백질과 지방을 합성하며, 자가포식을 억제하고 세포 복제를 증가시켜 암 발생에 영향을 미칠 수 있습니다.

mTOR와 관련된 효소인 아르기닌을 차단하는 연구는 임상 시험에서 항암 치료제로서의 가능성을 보여주고 있습니다.

요약하면, mTOR 활성화는 세포 증식을 촉진하고 자가포식 시스템에 영향을 미칩니다.

아르기닌이 암 발생에 미치는 영향

아르기닌은 단백질 mTOR을 활성화하고 산화질소의 합성을 촉진하여 혈관과 잠재적으로 암을 더 발전시킬 수 있습니다.

암 환자의 경우 아르기닌이 결핍되면 암 발생이 감소할 수 있지만 암이 아닌 환자의 경우 아르기닌 섭취에 대해 걱정할 필요가 없습니다.

특히 암 환자가 아닌 사람의 경우 맹목적으로 mTOR를 억제할 필요는 없으므로 AMPK와 mTOR 사이의 균형을 유지하는 것이 중요합니다.

영양과 운동에서 아르기닌의 역할

특히 비암 환자와 운동을 하는 사람은 아르기닌 섭취를 완전히 피하는 것은 권장하지 않습니다.

아르기닌이 암을 유발한다는 추측에는 근거 데이터가 부족하며, 암이 아닌 환자에게는 안전한 것으로 간주됩니다.

아르기닌은 글루타민 및 라이신과 함께 세포 생성에 중요한 역할을 하며 동화 작용을 하지만 암을 유발한다는 증거는 없습니다.

아르기닌은 체력과 전반적인 영양 보충 생활 방식에 도움이 될 수 있으므로 지나치게 걱정하지 말고 균형 있게 섭취하는 것이 중요합니다.