a few months ago I published this video about Brian Johnson, he's the multi-millionaire who is attempting to further anti-aging research by eating an extremely restrictive diet, by taking 100 plus supplements every day and spending a boatload of money. I was more positive

towards Brian's lifestyle than most people. I agree aging sucks and I find some of what he does inspiring, like how he prioritizes sleep and it has actually inspired me to take some steps to improve my sleep, namely I am eating earlier in the day, finishing

my dinner and everything I eat at 5:00 p.m., 5:30. 5 months later and I'm still eating popcorn right before bed, so it's going great, but at the end of the day this is not research. Brian is just one

person, no matter how much he tracks, how transparent he is, how many doctors he works with, he's just one person. No matter his results, his results are his results. So fast forward to 3 days ago and I get this email from Brian AKA Blueprint about his supplement line. It's

launching this Thursday, April 4th, so probably today when this video is coming out. It's called The Blueprint Stack and consists of extra virgin olive oil, Longevity Mix, Blueberry Nut Mix, Nutty Pudding, NAC Plus, Ginger Plus, Kirkin Red

Yeast Rice Plus, Odor-Free Garlic Essential Soft Gel and Essential Capsule. This is supposedly what he takes every single day. It works out to 361 total, $331 per month because the olive oil comes with two bottles, a bottle less a month. Yes, $30 olive oil. Shipping is free.

though so there's that so I would love to just say hey we don't need to do that like we can just stop here we don't need to go through and look at all of these because no one's going to buy this no one's going to spend this much money on

olive oil and blueberries and a multi but people will of course I mean not you guys probably people watching this cuz I'm willing to bet that Brian's audience is largely male my audience is largely not that regardless I'm going to do what

I always do with potentially scammy supplements I'm going to go through each ingredient and see if the marketing claims match the evidence let's go right down the list we start with extra virgin olive oil sourced from Australia or Portugal it's supposed to be very high

quality very high in polyphenols and it can support healthy weight management promote emotional well-being support health and longevity it's not vague at all he calls it snake oil as like a wink wink nudge nudge because people call him a grifter a snake oil salesman like okay

it's funny but you're also selling a 25 oz bottle of olive oil for $30 I seems kind of insane to me that said it is not unheard of the consumer lab top pick for extra virgin olive oil with high polyphenol content is

$26.63 for 6.9 fluid ounces so that is significantly more per ounce than the snake oil although it does have significantly more polyphenols than snake oil as consumer lab notes it's not clear if paying more for higher polyphenol content is even worth it so

Not a great start. Longevity Mix condenses over 20 capsules into a delicious sugar-free drink. Yeah, monk fruit extract, delicious. The number of overly sweet monk fruit extract things... Oh God, it's just disgusting. Vitamin C and magnesium, you can get plenty of this

from food. But okay, 2.5 grams of creatine, which is a typical daily dose, and this may be particularly beneficial for vegans and vegetarians, at least in terms of muscle gain. Evidence for improvements in cognition is less convincing. Calcium alpha-ketoglutarate, 2 grams, supposedly

supports improved frailty index in mice. Glucosamine sulfate promotes respiratory health and immunity. Glucosamine, along with chondroitin, is typically used to help manage arthritis symptoms, although results from studies are mixed. Now, there are several observational studies looking at glucosamine and respiratory

related symptoms. For instance, lung cancer. But a review questions the quality of these studies, concluding the studies cannot support the prescription of this supplement as a preventative measure for mortality, cancer, and other chronic diseases. Taurine, 1.5 grams. Brian doesn't tell us why we should take it on

the landing page here, examine.com, says that evidence for most outcomes is underwhelming, but they do give a B ranking for studies looking at taurine and blood pressure. Glycine, this is a non-essential amino acid, 1.2 grams. It may help with sleep and fatigue, but the

doses used in studies are more than double what is present here in Longevity Mix. All right, this is supposed to be for longevity, AKA living longer. The closest we've come so far to that is the calcium AKG, but again, squeak, squeak. Lysine, 1.2 grams.

while an essential amino acid, it does not hold much promise as a supplement beyond reducing the symptoms of herpes simplex. Brian telling on himself with this one. Seriously though, he should already be getting a good deal of lysine from his diet. He eats a good amount of

protein. He already takes protein powder. Ashwagandha root extract 600 milligrams, as I talked about in my recent Abby Sharp new theory supplement review, there is decent evidence for ashwagandha as treatment for anxiety and stress, possibly sleep improvements as well. And

600 mg is a typical daily dose. That said, Consumer Lab recommends choosing a brand that lists the amount of withanolides per dose. Brian Blueprint doesn't do that. Glutathione 250 mg, which Examine describes as an indirect and expensive way to provide dietary sustain, and evidence for any benefit is

underwhelming. Threonine 200 mg, another amino acid, there's some evidence for improvements in stress, anxiety, and sleep. And 200 mg is a common dose. Finally, we have hyaluronic acid 120 mg. Typically this is used topically or injected

intravenously, although there are several promising studies on oral use and skin hydration and wrinkles. So that's Longevity Mix. We have a powder with potentially small to modest benefits and a nebulous relationship to longevity. $39 a month. Blueberry Nut Mix. Now I do love that

it's called Blueberry Nut Mix and not like antioxidant superfood immunity complex or some [ __ ] right? It's just Blueberry Nut Mix cuz that's what it is: freeze-dried blueberries, macadamia nuts, and walnuts. One serving is equivalent to

half of a cup of blueberries, okay, you know, like just eat real food, but someone could say that to me regarding my protein powder consumption. I eat protein powder almost every single day, like I don't know if this is how people want to get in their

blueberries and Omega-3s. Whatever nutty pudding this is, the chalky stuff that he eats every day, it's basically a protein powder. It also has a whole lot of Omega-3s from flaxseed, three grams of ALA, 

which is a lot. Sunflower lecithin for choline, Ceylon cinnamon, cocoa, so more polyphenols because I guess the blueberry mix and the olive oil just just not not enough. The price is the best part though, $99 a month. NAC plus ginger plus curcumin.

NAC and acetylcysteine, this is the more efficient and cheaper alternative to glutathione. Brian says it restores cysteine levels because cysteine deficiency is so common now. A lot of the lung benefits are based on its ability

to loosen mucus when it is inhaled, so yeah, not really applicable here. There are studies on oral supplementation and specifically COPD patients with mostly disappointing results. Ginger extract for joint, liver, pancreatic, immune system, gastrointestinal health. Again, we're mostly talking about small studies with

a few dozen participants and not all of the results are positive. Finally, curcumin, the bioactive in turmeric. Brian wants you to take it for joint, brain, liver and kidney. Joint, yeah maybe. Brain, I don't know what does that even mean, like cognitive function, uh maybe depression, skepticism.

is warranted as the studies comparing K-Man to placebo were not well-designed and produced effect sizes not too far apart even though the differences were statistically significant. At least this one isn't 100 bucks. Red yeast rice plus odor-free garlic that's just something I

want to take, you know, sounds delicious. So both of these supposedly are for heart health. There is limited evidence red yeast rice can lower cholesterol levels, but this depends on the amount of lovastatin that it contains, and most brands don't tell you how much lovastatin

is in their product, including Blueprint. There is evidence for garlic and lower cholesterol levels too, but at much higher doses than what's in Blueprint Essential Softgel. We've got vitamin K, I mean, he eats so many vegetables like whatever. Lutein and zeaxanthin, these are

both carotenoids that may support retinal and arterial health. Several studies have found a relationship between both of these and cataract prevention, but any benefit is more likely to be apparent in subpopulations of individuals exposed to high oxidative stress such as heavy smokers, alcoholics,

or those with low dietary intake of carotenoid-rich foods. Evidence on arterial health is mostly limited to animal studies. Like astaxanthin for skin and arterial health, we do have a couple small studies like this one that suggested reduced sensitivity to UV light with astaxanthin consumption. Artery

health results are conflicting. Astaxanthin has been studied for a bunch of different conditions, is pretty underwhelming. Vitamin K2, both MK4 and 7, often taken for bone health even though the science is mixed. This recent meta-analysis looking specifically at postmenopausal women found an effect, but

the majority of the studies used combination therapy, right? So it was K2 and calcium or K2 and D3. Finally, we have the essential capsule. This is $55 a month for a multi and a few extra things like nicotinamide riboside. This is

gaining in popularity although this review is very critical of current scientific literature and it's got a probiotic of course. So as you can tell, I'm not super impressed by this supplement stack. I just hate supplement stacks. I hate that so much. I don't know

why, but I'm not super impressed and I'm even less impressed with the sciency nature of some of the marketing. So one thing you'll see on many of these is this clinical trial equivalent doses, which is mostly true. I will give him credit there, right? Most of the time when

I'm looking at supplements they are containing doses way less than what is actually used in the studies they're citing. Nine times out of 10, the Blueprint products contain the amount they should contain based on the studies that have been done, but that does not

mean this is evidence-based. Again, many of these claims are based on just a few small studies. So just because one or two or three small studies used, let's say, 600 mg of ashwagandha and found a statistically significant reduction in anxiety symptoms, doesn't mean that you

need to take 600 milligrams of ashwagandha to help with your anxiety. They can't even tell us that ashwagandha actually helps with anxiety. That's not how science works. Another example is this line in the email I got announcing

the launch of the blueprint stack saying that it's built upon 1,000 plus clinical trials sounds great in sciency except it tells us nothing about the quality of the trials but my favorite has to be this where he links to supposedly

scientific research it's just his own little experiment it's just an anecdote now I didn't bother doing the thing I really love to do which is to take all the stuff that's in the supplement I'm looking at and buy everything not actually buy it but to look on Amazon

and see how much it would be to buy everything individually you know again we're talking about what did I say $361 like even if you were to buy everything on Amazon it's still going to cost a lot of money you know once you're taking 67 powerful therapies like it's

not going to be cheap and again most of you guys are not taken in by this like you're smart enough not to buy any of this although it is lower cost than fast food do that what does that mean like I don't even know where to start with that

what's that mean just because we differentiate supplements from drugs for reasons doesn't mean that supplements are inherently safe they can have interactions with other supplements with prescribed drugs just like drugs can so if we look at glucosamine for example

that's in the longevity mix this interacts with blood thinning medication certain cancer meds Tylenol there's also a case report of it possibly exacerbating someone's asthma symptoms which leads to I think the big problem with supplement stacks like this one if

you're introducing just glucosamine or ashwagandha or whatever and you start having some side effects maybe you feel dizzy gastrointestinal issues whatever you can be fairly certain that that's what's going on at least you can say oh I just added in ashwagandha I'm going to

stop taking it and see if it clears up if you notice side effects after starting longevity mix or the essential uh Soft gel or the red yeast rice or all of them is it the garlic is it the probiotics and the multi is it the ashwagandha point is please consider

talking to a doctor before starting anything like this any sort of supplement stack especially if you already take supplements or on medications chances are any doctor is going to encourage you to hang on to your money and just eat right and exercise the thing that we can do today

is eat more vegetables go to sleep on time and exercise these are immediately in our control and this is again what I'm trying to show yeah this is really getting that message across Brian good job at the end of the day Brian is selling a product a very expensive

product that could presumably net him a lot of money he is incentivized to exaggerate the benefits he is incentivized to say yeah yeah yeah the basics but also this is the 20% of the work that's giving you 80% of the

benefits what so you're telling me if I take the supplement stack but I get 4 hours of sleep a night and I overeat calories I eat a bunch of you know donuts and [ __ ] and don't exercise I'm still extending my long

really regardless of his intentions again I don't think he is a grifter in the sense that he's like, "Haha, I'm going to make money from this con." I think he believes in what he's doing based on all of the videos and everything I've

watched. I could be wrong obviously, I can't read the man's mind, but again it doesn't matter because he's incentivized to believe that it's going to work. As a consumer, kind of don't trust anything he says, right? Go to independent sources.

I've referenced a couple of my favorites here: examine.com, consumerlab.com. They are paid sources, they don't have advertising or anything like that, so how they make money is with memberships. But even just going to like WebMD or Cleveland Clinic, you're going

to get better information nine times out of 10 than from the person who's selling you the supplement. Be skeptical and also don't be so selfish. I don't know, maybe that's unfair, but I... I like, if you're the type of person to spend close to $400 a

month to maybe possibly extend your life for who knows how long, maybe kind of maybe like, really, if you have that kind of money and that's what you're using it for, it's like, what's his name, that anti-aging researcher, you know, criticizing Brian, saying, "Hey, you know,

you could you could take that money and actually put it into research instead of um yourself, like you're you're using it to enrich yourself. Let's be real, that's what this is. But hey, I'll happily put $60 to $70 down on a new video game, not

not only is it not helping other people but it's arguably bad for me so you know who am I to criticize thank you so much for watching everybody I hope you enjoyed this I would love to know your thoughts about the blueprint Stack Down

Below how much you want to bet that olive oil tastes like [ __ ] that's really what I'm most curious about I want to taste that olive oil oh I bet it's nasty I think he said it's smooth and peppery

although I think like all olive oil is disgusting raw like I can only cook with it even when I make salad dressings I just use canola oil cuz it has basically no taste anyway please like the video and subscribe if I didn't already say

that and thank you so much to my patrons and my members I do post two exclusive videos a month for tier 2 patrons and members one is a vlog and one is a controversial I just posted the controversial topic for March and that's

it for me thanks again guys new video soon

The Truth About Bryan Johnson's Anti-Aging Supplements

The Truth About Bryan Johnson's Anti-Aging Supplements