poe 3.25 Guide to Sanctum: Prioritizing Loot and Avoiding Afflictions

In Sanctum, prioritize damage Boons, avoid bad Afflictions like Golden Smoke, and seek scrying Crystal for loot vision.

### Sanctum Guide: Boons, Afflictions, and Run Strategy
* 💰 " Raw currency is King, and **sanctum is the king of raw currency early**.
* 🏆  Prioritize **Boons over Afflictions**, focusing on **damage** and **scrying Crystal for room visibility**.
* 🚫  Avoid major Afflictions like **Golden Smoke**, which hinder **divine room finding**, and choose minor Afflictions carefully based on your character's **strengths**.
* 💼  Consider trading **resolve for inspiration** in curse packs, especially if you have **one Max resolve**.
* 🔮 " Every single piece of currency you get will make it easier for you to **complete more and more runs**.
* 🏃‍♂️  Sprint through gauntlet rooms to **minimize damage from fire traps**.
* 🧙‍♂️ " Put down your **two benit friends** on your enemy and then just **hop around, just hop around**.
* 💡 " If you're playing my league starter, which is **penance brand of dissipation**, do what I'm doing.

### Sanctum of Domination: Complete Walkthrough and Strategy Guide
* 🏰  The player navigates through various rooms on different floors of the Sanctum, encountering **different challenges and rewards**.
* 🗺️  Each floor has different types of rooms, such as the **Trap Guard room** on floor one and the **Desecrated Crips** on floor four.
* 🏆  The player strategically chooses between different options, like taking a curse pack for a chance at a **Divine** instead of guaranteed **chaos**.
* 💰  The main goal is to **collect loot**, with the expectation of getting at least **one Divine** and a certain amount of **chaos orbs per run**.
* 🗡️  Combat strategies include using the "**circle strategy**," where the player moves in a **circular pattern** while placing **brands on enemies**.
* 🧭  The player carefully navigates trap rooms, using specific techniques to **avoid damage**, such as **jumping through the laser beams**.
* 🎯  The final boss fight against Lysia is showcased, with tips on **positioning and avoiding her powerful attacks**.
* 💡  The guide emphasizes the importance of **smart decision-making**, **risk-taking for potential rewards**, and **optimizing loot collection** in Sanctum runs.

hello and welcome Exiles, to the guide for sanctum. The best money printer early on because raw currency is King, and sanctum is the king of raw currency early. Now let's get into it. Afflictions bad for you. Boons good for you. Yellow Boon purple Affliction major Boon. Most of them are bad, do not take trades for these generally. If you can get all seen, I go for it. Most of the other ones aren't that great. There's a few decent ones like trap disable, but don't think about it too hard. Major Boons might say major on them, but generally most of them are worse than a lot of the minor Boons. As for minor Boons, damage is King. The dagger, the less damage vial, or if you're playing energy blade, 50% more defense is also 50% more damage. Outside of those Boons, the scrying crystal, which allows you to see an additional room. This is very good for searching for divines, so I would prioritize damage, scrying Crystal.

and then after that things like Max resolve things like plus inspiration. Things like get an inspiration after every floor. That stuff is good too but prioritize damage then prioritize scene rooms. If your character already has a ridiculous amount of damage then scrying Crystal becomes a better option but if you need the damage to make it a little bit easier to guarantee the success prioritize that now afflictions these vary in difficulty and danger but number one worst Affliction you can get is Golden Smoke if you see this you are going to break your ability to find divines you're in sanctum to make money this is the worst Affliction in my opinion outside side of that other bad afflictions are things that limit your vision more like black smoke which makes you see one few room it's a much harder to find Divine rooms when you do that or things that just make it so you fail a run for example blunt swword here this is supposed to say 40% less damage I think I this might not be updated or

there was new patch notes that changed this. I don't know but things that might make you break the run. Blunt sword very bad the uh fish wings that makes enemies not able to be frozen makes them have a bunch more speed. You're going to hit a lot more things like Mark monsters do resolve weakness this not might not seem dangerous but it's basically just you lose 50% more Resolve from getting hit by enemies. It's actually quite impactful so play around how weak or strong your character is and have some level of idea of what afflictions are going to do in terms of your loot. Other notable things I should mention are liquid cowardice you could play around this by taking off your flasks the lose 5% current room resolve might sound very bad. It's going to chip you down but you can always click fountains throughout the run which make this not so bad or you can just trade a lot of your resolve for inspiration in which case this ends up not being too big of a deal anyways. The

point is read over the afflictions get a good idea of what they mean in terms of how much they're going to affect your run. For example, if you have a lot of damage, then an Affliction like Monsters having more life or blunt sword where you deal less damage might not matter as much. But if you don't have enough damage and it's really hard to kill those guards, then you really want to avoid those afflictions because it's going to make it so you lose the run because you're going to get hit a lot more if you can't kill the guards fast. Outside of that, a few notable ones I should mention: major afflictions might not be as bad as you might think. For example, Gastly Scythe losing resolve ends your sanctum run. If you have inspiration and you take inspiration damage, that will not proc Gastly Scythe. This is one of the easier ones to do if you have a nice little threshold of inspiration above you a lot of times on the handshake a curse packed agreements.

they will offer you a major Affliction for a lot of upside. Look over the Affliction if it's a major Affliction like this, and you have inspiration, you might be will just take that as a free option. Other good examples are like the unassuming brick. If you're closer to the end of the run, you already got all your Boons, and this thing says hey, you can't gain any more Boons, but it's going to take off some really bad Affliction that's bricking your run, might be a good trade. Cup purse cannot gain orus coins. By the time you're later in the run, this might not be a big deal because you've already um bought your Boons, you have some currency, and you'll be able to buy rewards. I should note here you can screw yourself with this. Say you have a four t or door tax. Say you have a door tax Affliction, and you click this node, and you're already at low orus coins. What could end up happening is you could soft

loock your ability to Buy Rewards because say you have you just spent all of your orus coins. you had 10 coins you're going into the next room you have this on you and it will break your ability to buy the next reward because every single reward where you're buying for the end costs five coins. It's relatively low cost but if you forget about something like this can break it so keep that in mind. all right that's the boons and afflictions let's get into a run this is a level 70 sanctum. I have my level 68 well okay technically my character is level 76 but I have eight less passes. this is simulating the league star character and I'm going to just walk you through Choice by choice I make when I'm choosing these areas waren sandals. this feels very bad makes it hard to dodge things you're going to get hit more generally I don't like this one red smoke. this isn't that bad if you know you can succeed no matter what run.

you do but take that with a grain of salt. If you're on the edge of completing a sanctum, this could be the difference in you failing and succeeding because desecrated Chambers are very dangerous on floor 4. Chamber of inscription concealed volatile anomaly. Volatile anomaly is annoying but I mostly can do this run relatively easy. Now looking at the rewards ahead of me, I don't really care too much about the fountain at this point because I have basically no resolve loss. So I'm going to go for the coins. You build up coins early so you can buy Boons later, and that is going to make it easier for you overall when doing the run. If that makes sense, we'll go ahead and curse these dudes, and we'll go over here. I will say this, this is something where if you play sanctum, you will start to learn the room layouts. The guards are always in the same locations, and the treasure chests on the side areas and the traps they're

always in the same locations, you'll learn it pretty fast. Every single floor has, I think, four types of rooms. They have a trap room, they have a Sprint to the end room, they have a fight kind of five guards throughout an area room, and they have a Battleground room, which has traps and you have to go through a series of like seven guards to complete it. Those rooms are typically the hardest. The Trap rooms is hit and miss, some of them are easy, the Sprint to the end of the room ones are the easiest, and then the basic five guards throughout an area are the in-between ones. All right, from here I noticed I have Chambers description, Chambers description, those are the type of runs, the room I just did where it's just a basic room. I want to get more coins so I'm going to go to another chamber assion, uh, chamber of inscription. This is the one where they have four guards throughout the rooms, um, these aren't as hard as the fighting guards in a trap.

area 'cause you have less you have to dodge, which makes it typically a little bit easier. Hopefully that guard died, I think he did, but we'll find out. And I could go around and click up extra coins throughout doing this run, but I am relatively confident this character is going to C while the will Cakewalk this sanctum, so I'm not going to Super try hard picking up extra coins. Now I want to show you basically what I believe to be one of your go-to rooms. You always want to prioritize URS packed rooms, so I'm going to start going over there through this chambers of description urse packed rooms. They always offer you three trade deals, and usually they are quite good in terms of you can get yourself some additional benefits that make the runs much much easier, as well as they always raw offer you a random reward, which means a cursed pack rooms could give give you chaos orbs, they could give you fusings, they could give you divines, and I would say generally I'd prioritize them over

any loot that is chaos or below when you're in floor three and Beyond. If you have Chaos on floor one or two, then maybe prioritize that, especially if it's early League. Now I'm going to go straight for the ACC curse back here. Let's see what kind of offer they give us. Generally, it'll offer some sort of trade like a downside versus an upside, and a lot of times, depending on what those trades are. Oh, also, this is a trap room. Trap room is basically you can Sprint to the end, have to fight the guards, whereas some of the other rooms you do have to fight the guards, and there's issues there. Now right out the gate, we have what I would like to say is the absolute best early trade you can do, and this is trading One Max resolve for a bunch of inspiration. This specifically is very good early because what it means is you can go to Future a cursive packs, and one of the things ACC cursive packs usually like to do is they like to say, Hey, you could give up 50% of your max.

resolve in order to get a benefit. Now you have one Max resolve that is a zero downside situation so I actually going to take this right out the gate. Specifically so that way when I get to more curse packs, I can just trade for a bunch of free afflictions. If you see this early, usually it means it's going to be a good run so I'm going to prioritize doing another a curse pack. I'm giving the monsters 50% more damage. My character is relatively squishy. This is a bit of a dangerous play to do and what that means is throughout the run, I might want to Target um getting the Boon that that makes guards or enemies throughout the Run deal 40% less damage. I think is what it is typically. That might be a safe play. Now I open up that chest and then I dodged out but I realized I don't really care too much about getting too many coins. Now you'll see right here it says lose 50% Max resolve gain two minor afflictions this

is a very good upside. I'm going to click this just because it's very valuable. Now you might say, Okay, you have three minor uh Boons here. And I have this thing where it says lose a minor Boon for lose a minor Affliction. This is one key thing I want to point out. I really like Gilded Liar. That was the Boon before I clicked gain two minor Boons. Something you need to note is when you get offered these options, the result is pre-decided. So if I click lose right here, it would delete my Gilded Liar. It would delete that. And in return, it would delete, well, I guess I think I had all these three afflictions before. It would delete one of these randomly. So keep that in mind when you're choosing these. It might be kind of clear whether or not it's a risk or not a risk. So for example, say I didn't have a good Boon and I had some bad afflictions and the Boon I had before I got these two Boons. Say I got

two really good Boons after having a bad Boon. I know I could take that lose option without losing the good Boon, so I'll demonstrate that real quick here with the lose Miner for minor. It's going to take away my guilded liar and leave the other two. Now that's not a good way to do the run. I'm making the run harder by doing this and I traded it out for an Affliction that I don't even know what the Affliction was volatile anomaly. I guess that's kind of annoying sure it's an upside, but it's not a particularly good one. Now next up, Mark of Terror versus purple smoke. Purple smoke means afflictions in the future could be very very bad for me. This is a heavy risk taking early versus Mark of Terror. This thing makes enemies are going to impact my resolve at 50% higher. Very dangerous, but I feel pretty comfortable for the most part. I don't think I'm going to hit get hit very much throughout this run, and I'd rather avoid.

getting an Affliction that would completely and entirely brick my run like Golden Smoke would. In terms of making currency, so I'll take the risk of being a little bit harder, a little bit more likely to fail versus the risk of just outright having a bad time and not actually making currency. A lot of times purple smoke becomes less and less risk the farther you get into your run, but you need to like kind of have some I don't know thought process on how you assess the risk in terms of how far you are into your sanctum run. Hopefully we're doing okay here, nothing will go bad. If you're playing my league starter, which is penance brand of dissipation, there's supposed to be a third guy. Okay, I was like where did this dude go. Um, if you're playing my leak are, which penis brand dissipation, do what I'm doing, put P put down your two benit friends on your enemy and then just hop around, just hop around. It's not too complicated, go in a circle, uh, Afflicted.

Fountain basically never click this unless you're at the very end of the run, and you desperately need resolve. It's just usually not worth it. All right, and then this boss, we're going to employ the strategy we do for every other enemy in the game, which is we put down our penis brand, we put on our assassin's Mark, and we just kind of run around. And this is going to be the case for most bosses you're going to run into. Um, oh my word, no wonder I was okay. Something that just occurred to me when I was doing those like the last two rooms, I was like my damage feels bad. This is something that you should be a little bit aware of. I had turned off my energy blade, and I didn't realize it. I was kind of wondering where my damage went. That's where I went. I accidentally turned off energy blade. I don't know at what point I did it. Now the reason I have energy blade on my keybind is because specifically at the final boss, there's a

wave phase that's a little bit dangerous. In order to play around the wave phase, I like to turn off my energy blade because it makes our es higher, makes us a bit tankier. So that way, if we misplay it a bit, we can take a hit or two more than we would be able to otherwise. Now, next up, we have voodoo doll Merchant prices. Gargoyle, gargoyle is relatively easy. If I want to do it for the chaos, that's what I do 100% more more Resolve loss while at 50% resolve or lower. This is kind of free because my character has one resolve. But outside of if you don't have one resolve, then this is actually quite dangerous. I think I'll probably go with the um chaos orbs here just because I'm trying to get loot. We're trying to make currency early. League currency is King, and every little chaos is another upgrade we can make on their character, which is going to help us snowball into doing better and better at sanctum. So that's my general advice if you're

choosing between two relatively non-bad afflictions, prioritize the money. CU every single piece of currency you get will make it easier for you to complete more and more runs. Next up, we have an ours pack versus a merchant. Both of these are going to be good upgrades for my character. I'm going to go for the accursed pack specifically because I have one resolve, and because I have one resolve, that means everything is just super high value in a curse pack. Because I get to take those trades that allow me to trade Max resolve for inspiration, and just feels really, really good in that regard. I don't get hit by anything. Now right now I'm with my 68 character, I would have already leveled once or even twice, and your first San you get a lot of XP, and I would have prioritized the plus two brand node which allows me to have two Brands per each enemy. Usually during sanctum, you fight about two guards per time, so if you're doing a brand build, having the ability to cast at least four Brands is

typically ideal now looking at this I have a choice to make here. I could go for this a curse pack, which is what I was planning to do, but you'll notice it only has one way for me to go, and that's into monster life. Versus up here, I can get another curse pack, but I don't take on the Affliction. So when you're trying to make a choice like this, monster life is pretty bad. You don't really want that. You don't want to make the monsters tankier. You want to kill them fast, and you want to keep on moving. This run is the Trap room. Now, I would advise you do what I do on this room, which is Sprint Sprint every single time you get to this room, which was called the. I forget what the room. I'm whatever for whatever reason. I'm spacing what the room is called, but Gauntlet. Gauntlet is always a room where you can Sprint just like that, and then you don't really have to think about it if you

don't sprint just like that. The fire traps are a bit harder to navigate and you could take some resolve damage. So keep that in mind when you get to this room. I recommend just sprinting through. It works out typically really well. This guard is always like a time waste guard cuz he constantly just takes off the brand you put on him. Refuses to die. Kill every other guard before I kill this guard just because. Just keeps teleporting. Keeps taking off the brand and could be a bit annoying. All right now as you'll see here gold trophy lose 25% resolve. I only have one resolve so this is a free remove. Mless chorus versus remove arrowheads. I do not want to remove this this thing. When you have inspiration basically allows you to take twice as much um in or damage for to your towards your resolve or towards your inspiration. Very good if you have inspiration currently in your run outside of that. I have a gain random for a gain random never take this. The risk is too high unless you're

really trying to push Loot, and you're just saying, okay, I have I'm having a good Runo even if I have a bad Affliction. I can probably still win the run, and it's just your only decent option. Like the other options are just terrible. That's the scenario where you take the minor for a minor, but generally I would say avoid it because you can get some really bad afflictions that could just wreck your run, and you don't want to do that. Fenix Wings, very bad Affliction, makes the guards faster, you're going to get hit a lot more, get a lot more chip damage. I'm going to avoid that one since I have that Choice versus rusted coin. Rusted coin is also decently bad, but I'd rather have rusted coin and just keep greeding Boon through cursed packs and maybe just not worry about the merchant for this run because we got that earlier Boon. It's a little bit harder of a choice if you don't have a lot of good source of afflictions.

ultimately, I would recommend just avoiding things like fish Wings because you will take chip damage throughout the run, and Chip damage throughout a run is how you end up failing. Just personal advice I would give to you in that regard. Okay, uh, I forgot a guard or rare every single, uh, this is the zone that is a um kill five guards. You need to kill like each rare and each guard in the room before you can do the door. It's not a Sprint to the exit room. It's the more normal one, and that room was called de derel Caverns gauntlet is the Trap room where you can Sprint to the end, and decrepit Cellar is the actual Sprint to the end room where you just have to go to each Four Corners. I don't know if I described that earlier. Gauntlet radiant Fountain, radiant Fountain, these are like a high priority, especially if you want to make your Runner easier. Target them. They give you 200 inspiration, a free Boon, and they remove an Affliction if

you're having a hard run go for these. The only thing you would choose over radiant of a fountain is basically like a really good loot option if you're trying to push. Loot and you already have some good rewards so I'm going to go for the Der like Caverns, which is another room where we have to kill the rares and the guards in each room. And so I'm going to do that now. There's sometimes a rare down there, sometimes there's not, you always want to check there, otherwise you have to run back through the whole room and that can feel kind of annoying. I would say this guy I killed everybody, no there's a rare somewhere probably that I missed, there's probably a rare. These rares are really annoying on this Zone specifically cuz they like to jump up late after you've already feared everything. I just don't know where it is, okay now the stairs are available I guess there was some rare I didn't see, I don't really know at what point but anyways moving.

on radiant found what type of room is it. it is a gaunet so I'm going to Showcase this again gaet rooms look like this you Spa you spawn downwards with a wall right above you. what you want to do is you want to Sprint. so you want to do frost blink leap slam leap slam Frost blink. basically you want to do something like that where you're getting out as fast as possible. and I messed up there I wasn't quite as fast I did the wrong order of things but the idea is at most you're getting hit by one of those Fireballs if you do it correctly or zero. in which case you get through the room very fast so we got 200 free inspiration from radiant fountain that should make this run very easily. and on top of that it removed one of the afflictions I have so that's one less reason I'm taking damage now removed resolve mitigation. our character doesn't really have armor so resolve mitigation isn't beneficial but it is what it is now as for this gr uh

this room this is the boss floor Fight 2. This one is a little bit different this guy. I think is a little bit harder to dodge attacks. I always prioritize killing him first whichever one you kill the other one will go back to full HP and get like an extra attack or two or extra mechanics. Basically what I recommend is PR izing this guy cuz I think he's a little bit harder to dodge. Kill him first and then later on target this dude. He's going to do a orb if he gets to it. Okay he didn't get to it cuz he didn't have enough attacks. He'll do a thing where he raises a blood orb. Basically just run around until he drops or behind you. That's probably his most dangerous attack and it leaves a de gen pool on the floor and just you just need to not stand in that. Okay so that is floor two. I think the only room I didn't showcase there was the haven't gotten to show case any of the rooms where it's just your F Well I

did trap guard Battleground rooms on floor one, but I don't think I found one on floor two. Uh, floor two, those rooms aren't too bad. Floor three, those rooms aren't too bad. Floor four has the bad rooms for desecrated Crips, and those are the ones you want to be probably avoiding. More now we have blunt sword, very bad for damage. I'm going to avoid that empty Trove, not really ideal. Voodoo doll, I have one inspiration, this is free on other runs, this is something I would probably avoid more, but since we already have that one resolve, I'm going to go ahead and take it. This is a trap guard room on floor three, relatively easy. Most of these rooms I would recommend just going in a circle and don't get hit like I did just there. Um, but yeah, just go in a circle, place your Brands, that's all you really need to do. Don't overthink it, that's the case for 90% of the rooms in Sanctum, just go in a circle, put

your brand on enemy go in circle. That's all you got to do. Don't overthink it. Just leap slam, go in circle, and eventually all the guards will be dead. You see, they're dead. Circle strategy remains Supreme like everything in Poe. It's always worth. Okay, remove gargal, remove, increase resolve recovery since I have one resolve. This is an irrelevant Boon. And this thing's a little bit annoying because sometimes my penet brand is put on a gargoyle instead of the Guard. 25% resolve Ross. This Boon is not beneficial to me at all, but I want to take it anyways. And the reason is the more random Boon you stack up, the more likely it is the next Boon you're going to get is going to be one of the good ones. Do not take this unless you are just trying to push Loot and it's the only option cuz the other options are really bad. GS would have probably been a bit more valuable at this point, but oh well. Exalted orb versus bless.

orbs early on. I think Exalt Orb is probably worth more, so I'm going to prioritize that. This could be a Divine floor. Three can start dropping Divines, but there aren't any available to that yet. This is the floor type where they put random five guards throughout the room, and sometimes some rares. The rares can be anywhere from zero to like five rares. I've seen on rooms like these the rares are typically the most difficult part of these if you get some bad ones. But regardless, these rooms should be relatively easy. Those guys should be dead, and I'm going to go over here and hopefully finish these dudes off without too much issues. All right, we are actually collecting a lot of coins from our gold trophy. The next time I buy a boon, I think I lose gold trophy, so if the merchant is good, I might do it now. Halls of worship, we just did. Okay, we just did Unholy Lir Infernum is the fight, the guard fight room in floor three, Unholy.

lir is the fight through five guards, plus a rare, to open the door at the end. Unholy or Halls of Warship is the this is the easy room you can just Sprint to the end, and Crucible is the Trap room. I'm going to show both of these. Crucible and Halls of worship are both pretty easy on floor 3, and I will showcase that. As for the Sprint to the end room, it's basically always you need to check Four Corners. That's how Sprint to the end rooms work. It's the way it works in the first floor, the second floor, third floor, and the fourth floor. Halls worship, I like to go up the stairs first and down this hallway and check the first corner, and then you just make a rotation until you find the basically the exit. The exit can be in any one of these three locations. It is just randomized, and you just need to check all three. Sometimes you'll get it on the first floor or the first Corner. Sometimes it will be the last corner. It just kind of varies all.

right exalt orb acquired. I don't really care about doing the merchant, but I care about this curse pack. A curse pack is always more loot and a chance for rolling a divine, and I always want to go to those. Um, a curse packs are probably priority rooms, uh, most of the time, especially on 4-3 and 4, but on early floors, uh, coin rooms and merchants can be quite ideal 'cause they could set you up with getting you a good boom throughout the run, etc. All right, so we got here. She only has one option. It is more gold coins found. I'm just going to ignore that. I have 2,000 coins from the gold trophy that's been stacking up. We are going to keep going handshake room. Hopefully we get some divines, and it is an infernum, which means we need to just simply walk in a circle. Just go in a circle. That's all there is to it. Just go in a circle. I should say, uh, specifically about these laser traps. You'll see them.

in multiple different rooms. And you're going to grow to hate them, but they're not quite as hard to dodge as you might think. The point these things do resolve damage is only at the very tip of the laser. So, for example, if the laser is extended out in front of you, you can jump through the laser if it's at any point but the very tip where it's hitting the ground. Um, this will be much more relevant in desecrated CPS, which is probably the hardest trap room to learn because it has four laser rooms and very awkward positions, much harder to dodge through. But there's a lot of scenarios where you can go through a side area and you'll be fine. All right, a bunch of more free trades where I get to trade resolve for benefits up here. If I was really on having a rough run and I was about to lose to resolve loss, I would consider this trade because this is a very dangerous Affliction. But considering the run is going pretty well, I'm not really losing the resolve I'm

not in danger. I do not want to take the risk of getting Golden Smoke and then breaking my ability to find loot throughout the run. So I'm going to not take the trade three Val orbs not too shabby we take those a curse pack. I am probably going to go for Golden smack smoke very bad vortx is it's whatever we have a lot of booms at this point from random booms we've gotten throughout doing trades. I am going to take the traps impact 20% resolve this could break my run CU traps can be very dangerous on floor four. But I am an addict for Loot and I'm going to take the risk. There is a scenario where I lose to that just because the desecrated uh Crips is very hard to do to avoid trap damage and there are a decently amount of trap rooms on or or that can be semi- problematic. But I'm going to take the risk because I make bad decisions on a regular basis and that's just that's just what it be.

sometimes, okay, there is a rare we forgot or this guy. I guess I didn't kill, all right now we have a free Boon for clicking in a fountain. I'm going to buy that because I have a bunch of coins and it could have been something good. Golden Smoke bricks my ability to find loot. If you click that, you basically already lost the Run cuz it's going to kill your ability to find divines. Just avoid that at all costs unless it's at the very, very end and you already know what the rooms are in front of you. The Golden Smoke will change your ability to see what's in the room, but it doesn't change what was there. So for example, if you knew a room had a Divine and the room before it had Golden Smoke, that's a scenario where you would take Golden Smoke. You say I'm going to risk it for losing loot in the future to guarantee this run hasn't fine. That's like that's a trade that's worth taking where you take golden smoke cuz it's not

going to change the loot that's in this run lose 200 resolve 4 100 inspiration. I cannot click this 50% less resolve B loss in Boss rooms versus 100% more Resolve loss in non-Boss rooms. This is actually very problematic especially since I clicked 200% trap uh damage done to me. This is a scenario where both these options are bad. I can't click this one. I can't accept it because I have no resolve to give. It won't kill you even though I only have but it just it just says you can't do it. This one I think would make me lose the run if I click this plus 200% uh traps and pack damage. I could just die to traps very easily. So what I'm going to do is I'm going to take this. I'm going to gamble on the random Affliction because these other two I can't do or just way too risky. And hopefully we just don't get a bad Affliction. We will see what happens but sometimes you just got to take the risk.

because I want loot, and I think it's worth the risk. Merchant offers for your choices. That is fine. It could have been a much worse affliction. It wasn't. Usually you'll get by Scot-free. So that's why I think it's worth taking the risk to get a chance at a Divine. But only take that risk on floor three or four where you can actually drop a uh. You have challenged my where you can actually drop a Divine. I wouldn't do that risk on floor one or two 'cause you can't get divines on floor one or two. Chaos orbs are King. Chaos orbs are King. Give me give me loot. All right. Now we're going into the floor number four, the final and hardest floor because it has some of the hardest rooms desecrated crips and tment desecrated CPS. So these are all semi-bad rooms desr CPS is the worst. This is the one where you have to fight guards. Dodge lasers. It's a lot more problematic and a lot more dangerous attuned is the Trap room. I'm

going to do desecrated CPS because I want chaos or do I uh you know what now that I think about it I would rather go a curse packed and this is something that I'm going to say over and over again a curse packed. It's better to take the chance of getting a Divine over taking the guaranteed chaos in my opinion because there's a likelihood you could get chaos from in tment anyways. And so I have the choice between what guaranteed I think it's like four chaos or whatever it is versus could be two divines. I'm going to take the risk because that upside is just too big in my opinion and even even if I low roll I don't get chaos I might get Valor or something else that's valuable this room the Trap start late if you're fast enough you can go straight away now this second part over here the way I like to do this part is I wait for a fireball to not be coming and then I jump over and I frost.

blink to the side. Next up, there's going to be a guard over here. We can just kill him to make it more safely, or you can sprint by this guy if you are an absolute gamer. But I'm going to play it safe. I'm going to proc this trap. And now what you do is you wait here for these Fireballs to be separated, for there not to be one following this one. So if you don't see an animation, you can go ahead. And you have enough time to jump over here, jump over here, jump over here. And you've avoided the Trap rooms for this in tement floor. And you haven't gotten hit. I might have got hit by something though 'cause I'm at 380 inspiration and I thought I used to be at 400. I wasn't paying attention too closely. Okay. Unholy ear. I could get a curse packed up there versus uh fish Wings. I'd rather just have the Unholy earn. So that's what I'm going to go for.

and then we'll work our way through the next rooms. Unholy earn is bad if you have good relics, good if you don't have. Not a big deal if you don't have good relics, that sort of thing. This thing is basically scario where you can just take it slow or if you're used to the patterns you can take it a little bit faster. Um, they're always on a delay and then there's one guard over here. Um, technically you can like really Sprint through this if you know the pattern very well, but I'm just kind of going slow just to Showcase all right, remove this for removing resolve loss. I really like this especially when I'm playing a squishy character. This character kind of on the edge of survival. It's very early gearing. Um, I like fright mask early later on it won't matter as you gear the character up, but early on it's a nice thing to have. Gain a miner for a minor. I don't really want to do that and I have gain rusted Chimes.

for gain random minor rusted chimes, is a decent random minor [Music] Boon. I would rather take the chance at getting a dagger or more defense, or scrying Crystal. All of those would be better, in my opinion. I don't like this option. I don't this option's okayish, but I'd gamble on a better Boon. I want to check whatever loot is there, so I'm going to risk the minor Affliction. Just don't do it on the earlier floor. Trap impact reduce resolve, that helps a lot because it helps mitigate that earlier Affliction. I got enemies ignore your resolve mitigation, that is not bad for me. I will take Divine vessels. Divine vessels on day one are like 5c. Divine vessels on day five are zerc, so always keep track or have an idea of what is worse of and what isn't worse of. Now ideally here, if I was trying to win the run, I would go for inment specifically because it gives me a boon here, but I want to showcase a different

room so I'm going to Showcase underc which is the Run to The Corner Room lost catacombs is the fight five guards and two rares and then the door opens underc is the four corner room so I'm going to Showcase this one um just to give you an idea of what the room looks like I always just sprin directly to Each corner check them and if they're not there I move on um and I would recommend doing the same if you're doing four corner rooms it's not really beneficial to fight the guards you just have a chance to get hit while doing it and not fighting the guards you just are going to get through the run quicker and faster runs faster getting to loot desecrated CPS fantastic this is the worst room or the most difficult room to learn in my opinion four quad lasers positioned at very awkward points that will shoot inward towards you I am going to do the thing I told you earlier which is I want to avoid the tip of the laser and I can jump through the beam so

while I'm doing this run if you see me jump through the laser you might notice I don't take damage. The little tip of the beam it has a bit of an AOE so sometimes if I'm too close to it I will get hit by it but that's what I'm going to be doing in this floor here or show trying to Showcase like I extend this thing over and then I jump out to through the laser and it works fine. A lot of times you'll practice luring these beams over to like points where you aren't and then you can jump through the laser at the um I don't know where it's extended or whatever if that makes sense. Okay, we took some beam hits there it did a lot of resolve damage we need to be a little bit more careful um cuz we were taking a lot of resolve damage we are suffering from that Affliction where we took extra trap damage but I was cocky and told myself I wasn't going to lose and for the most part we only took 8.

resolve damage. It's probably going to be fine. Do I have a boon for gaining Boons when I click a fountain? No, so we're not going to do anything there. We're going to keep moving. All right, uh, lost catacombs. Lost catacombs. This is basically just choosing between which room gives you more loot, and they both are going to re-lead to floor, uh, to three rooms. So I'm going to go here, get the choice at chaos or chaos, and we'll see what it gives us. This is the basic room that has five unique guards. We're just going to go through and kill them and then move on with our lives. Um, sometimes there's rare, sometimes there's not. This area has three of these dudes. Just practice the age-old principle of go in circle, don't get hit, and that's all there is to it. Part the reason that I recommend Penet brand. Hopefully, is very apparent at this point, and it's because I don't have to stand still. I can keep moving the entire time, and I won't lose the

run all right uh looks like the best chaos reward is here so I'm going to go top side. Top side which means we have to go through another desecrated CPS so we'll showcase another one of those and then a underc. This run was a bit unlucky we didn't get the vines I would say. Usually loot wise in sanctum if you're playing it correctly if you're searching out scrying Crystal if you're taking a bit of risk and making sure to always keep your vision of possible future rooms as a large amount of them you should get. I need to be a little bit careful being a little bit in danger. All right we're fine only L for we resolve. Anyways as I was saying if you're always being a bit smart about where you're picking your rooms it's like for example I didn't do great on this uh this top side route would have had more Vision on more rooms throughout the run which potentially could gives you more chances at divines but going scrying Crystal you can open

up a lot of that Vision. I think sanctum runs, one in every two run, you'll get a Divine. Usually, if you don't get a Divine, you're going to end up with anywhere from 30 to 50 chaos and some other miscellaneous currencies, scours, etc. Especially that number goes up when you start doing the um later floors like in terms of like level. Like right now, I'm doing a pretty low-level uh sanctum example here but eventually you'll start doing sanctums that have you know 83 sanctums where the last chaos reward is 14 SE instead of six chaos. All right, level 73 Zone. We are fighting lysia. How I always play this fight, it's pretty much always the same way. I stand a little bit to the left of her over here. I preload my banners. She's going to dash towards me and I am going to go in the corner, get Assassin's mark on it. She's going to dash again. She's going to start doing uh her laser thing okay that is not usual. Normally he

starts doing maven's gaze there and you just duck behind the wall or doing that extra Dash animation ended up being like fine uh cuz maven's laser is the main thing or maven's gaze whatever she calls it B bat's gaze. I think I don't know laser thing kind of hard to Dodge in that first area uh it's easier when she's in this Zone don't go in the corner but anyways you just kind of stand behind her you can rotate around her when she's doing that that's the most dangerous thing. The idea is if she's in that corner shooting the laser you can just duck behind the wall and not get hit by it she did a weird Dash which is not normally a mechanic she does it is what it is now. I'm going to showcase the fight um I'll put the brands down and then we just go to jumping around this beam she's doing does a little bit of chaos damage there are very few things in s that do chaos damage but that's one of them. Also those

swipy swipy blades do chaos damage. I'm going to turn off my energy blade here. You'll notice I went from 3K to 5K. Yes, the reason is if I do this fight incorrectly, if I play it poorly, that extra 2Ks could be the difference in me failing or not failing. And that's why I have a weapon that is a weapon I can leap slam instead of like a wand as my energy blade, for example. But I recommend being on the bottom side of. I think it's easier to see the waves and then put the thing, put the brands on her and just jump around. As I was saying, we have 70 chaos res on this character. There are Chaos Attacks. They shouldn't one-shot us for the most part. That beam is close to one-shotting us depending on what bound you have. If you have the 40% less, that's the difference in it probably one-shotting versus not going to circle on the beam. And as for the swipy swipy blades, try not to get

hit by those cuz they do do they do deal a bit of chaos damage. Oh, all right. Hopefully this was a good showcase of sanctum. We got, I don't know, 20 something chaos. I think I had about 40 chaos before we got an exalt, got some extra fusings. I should have cleared out the loot in this guy's inventory before we started the run, but I forgot to. That was honestly a really low value sanctum. Like that is like Min rolling on value, and it's probably because I don't know throughout the run I might have made some mistakes. Not 100% sure. Sometimes you just get bad RNG. For the most part though, I'd say at least every run you're getting about a Divine plus some chaos. Usually every other run you're seeing a Divine, and the raw chaos ends up being worth quite a lot because early League divines are 40c, 50c, 60c, 70c, etc. And on top of that early League certain um unique relics that Lysa drops.

balance a terror balance of Terror are very valuable early on. If you can do some early runs with that, uh, there is the value in being able to get the, uh, sansur vicious Relic or some of the other unique relics. I think vicious Relic, they're making RAR, and that might be a higher level Relic. Now, we're not sure. Anyways, that was the sanctum run showcase, giving you a walk-through of how to do sanctum, thought process of how to do, uh, picking your afflictions and Boon, hopefully giving a good demonstration of what you're supposed to, what the gameplay should look like. Anyways, thank you for watching exil. Hope you enjoyed. Take care and peace out.

How To Sanctum? Walkthrough + Basics

CaptainLance9

Sanctum is the best early game money printer due to its raw currency rewards.

When choosing boons and afflictions, prioritize damage-boosting boons and the scrying crystal for room visibility.

Avoid afflictions like Golden Smoke and Black Smoke, which limit your ability to find divine rooms.

Major boons are not always better than minor boons, so focus on the ones that enhance your damage.

When considering affliction trades, assess their impact on your run and consider using inspiration to mitigate major afflictions.

Be cautious with the cup purse affliction, as it can limit your ability to gain orus coins for buying rewards.

Always keep in mind the potential consequences of affliction trades to avoid getting locked out of buying rewards.

Navigating the Sanctum: A Guide to Room Prioritization

Prioritize collecting coins early to buy Boons later, making the overall run easier.

Usher packed rooms should be a priority, offering three trade deals and a random reward.

When making trade deals, consider the potential benefits and downsides carefully to optimize the run.

Making Strategic Choices in a Video Game Run

Choosing boons and afflictions can impact the difficulty and potential success of the game run.

Prioritizing currency and character upgrades is crucial for long-term progress in the game.

Making strategic decisions based on the character's abilities and the potential risks can ultimately affect the outcome of the run.

Navigating the Game Room and Making Strategic Choices

Sprinting through the fire trap room can result in resolve damage, so it's advised to proceed with caution.

It's recommended to eliminate every guard before dealing with a particular persistent guard to avoid wasting time.

Choosing the "lose 25% resolve" option can be beneficial if having only one resolve, as it allows for a free removal.

It's generally advisable to avoid taking the "gain random affliction" option, as it can negatively impact the run, and to prioritize removing afflictions that cause chip damage.

The "Radiant Fountain" room is a high priority for gaining inspiration, a free Boon, and affliction removal, while in the boss floor fight, it's suggested to prioritize targeting a specific enemy to make the battle more manageable.

Sprinting through the "Gauntlet" rooms and prioritizing certain actions can make the run easier, while being mindful of the different room types and strategic choices.

Navigating trap guard rooms on different floors requires specific strategies, with floor four having the most challenging rooms to avoid.

Prioritizing valuable items over less useful ones can help optimize the run.

Sprint to the end rooms and curse packs are priority rooms for better loot and a chance to roll a divine, especially on the higher floors.

It's important to make the most of resolve trades for benefits, especially in challenging runs.

Risking It All for Loot: A Gamer's Dilemma

The speaker is taking multiple risks in the game to obtain loot, despite the potential negative consequences for their character's abilities.

They are willing to gamble on various in-game options, prioritizing the chance for valuable items over guaranteed benefits.

The player emphasizes the importance of taking risks for loot, believing that the potential rewards outweigh the possible setbacks.

Navigating a Gaming Level with Expert Tips

Take it slow or sprint through the level depending on your familiarity with the patterns and guards.

Utilize specific strategies to minimize damage and resolve loss while navigating the rooms.

Make smart choices to maximize loot and increase your chances of success in the game.

Tips for Navigating the Sanctum Run in Path of Exile

Sanctum runs can provide a mix of chaos and other currencies, with the potential for valuable divines and unique relics.

It's important to maintain high chaos resistance to avoid being one-shotted by the chaos damage from the boss.

Paying attention to mechanics and optimizing gameplay can maximize the value of each sanctum run, despite the potential for variation in returns.