Bufotenin: A Weaker Hallucinogenic Relative of DMT

Bufotenin, a weaker hallucinogen, is chemically similar to DMT and sourced from toads, trees, and fishes.

### Exploring Bufotenin: The Lesser-Known Psychedelic Compound
* 🧠 Chris discusses the similarities between bufotenin and dimethyltryptamine (DMT), highlighting bufotenin's chemical structure as **5-hydroxy dimethyltryptamine**.
* 🔬 Bufotenin retains the DMT structure but adds a **hydroxyl group to the five-carbon position**, distinguishing it from serotonin.
* 🌌 While bufotenin has weaker hallucinogenic properties than DMT, it still possesses some **psychedelic effects**.
* 🐸 The molecule can be sourced from various natural entities, including toads, trees, and fishes, although reports of **psychedelic experiences from "licking a toad"** are rare.
* 🌳 The discussion includes the distinction between poison and venom in the context of toads, noting that **further research is needed to clarify this aspect**.
* 💉 Like DMT, bufotenin requires **injection or inhalation** due to **extensive first-pass metabolism**, limiting its use as a psychedelic.
* 🔍 Chris emphasizes bufotenin's **minor role** in the psychedelic landscape, yet its chemical similarity to **DMT and serotonin** makes it an **interesting topic of discussion**.

Good day everyone. This is Chris back again with the ancient scholar. We continue talking about the psychedelics, the serotonergics, and we'll talk about the next molecule which is structurally very similar to dimethyltryptamine. So if we take a look at our serotonin molecule, our original serotonin, we have 5-HT or 5-hydroxytryptamine. I have a hydroxyl group hanging off a five-carbon on an aromatic ring, and then I have an amine side chain here. And we know that if we get rid of that, okay, we oxidize the aromatic ring and get rid of, or reduce it rather, and get rid of the hydroxyl group, and then substitute the hydrogens with methyl groups on the nitrogen here, okay, that produces, there we go, that produces a molecule of DMT or dimethyltryptamine. All right, and we've already talked about that. So the next molecule that I'm going to talk about is something known as bufotenin. Bufotenin is also known as 5-hydroxy

dmt or 5-hydroxy dimethyl tryptamine. So what does that mean? Well, that means that I don't revert back to serotonin; rather, I keep my dmt molecule, okay? My dimethyl with my two methyl groups here, I keep those, and the only change I really have to do is just to put that hydroxyl group back on the five carbon there, okay? So now I have five hydroxy dimethyltryptamine, and this is a molecule of bufotanin. Bufotanine is a ha is a weaker, has weaker hallucinogenic or psychedelic properties than dimethyltryptamine proper, but it still does have some hallucinogenic properties. And three areas that you three places you can get this molecule from: it can come from toads, trees, and fishes. And there is the term licking a toad. That term does tend to come from this actual case reports of actual psychedelic experiences happening by toe licking are kind of rare, to be quite honest, and it seems to be a little

overblown, but certainly it could come from the beans of several different species of trees. There is a toad, um, towed venom. I would have to actually research that because to call something of venom means that there is a delivery mechanism involved. And when we typically talk about frogs and toads, generally frogs specifically, I know toads aren't frogs, but frogs excrete poison. They don't have a delivery mechanism for that poison. So it may be that the toad maybe has some sort of way of injecting the venom in their mouth or what have you. If that's the case, then I think, uh, it would be justified calling a venom, but I'm not sure if it's poison or venom. But be as it may, it exists. Um, it's, it's not neces, not nearly ha, it doesn't nearly have the hallucinogenic properties as DMT. And just like DMT, it really pretty much has to be either injected or inhaled because of extensive first-pass metabolism. So it's kind of a minor

player, but it's a quick, easy one to talk about because it's just so chemically similar to DMT and serotonin. Okay, guys, as always, thanks for hanging in there.

Psychedelics (Serotenergic Agents: Bufotenin)

TheAncientScholar

Bufotenin, or 5-hydroxy dimethyltryptamine, is structurally similar to DMT, with the only difference being the addition of a hydroxyl group on the five-carbon.

This molecule has weaker hallucinogenic properties than DMT but still possesses some psychedelic effects.

Bufotenin can be sourced from toads, trees, and fishes, although reports of psychedelic experiences from toad licking are rare.

The toad's venom delivery mechanism is unclear, as frogs typically excrete poison without injecting it.

The toad's venom is not as hallucinogenic as DMT, but both substances require injection or inhalation for effectiveness due to first-pass metabolism.

The toad's venom and its properties are still a subject of research and debate.

The Chemical Similarity of DMT and Serotonin

DMT and serotonin are chemically similar, making the discussion about their relationship quick and easy.

The speaker appreciates the audience for their attention.