Factors Affecting Eye Color Changes

Eye color can change due to various factors including genetics, aging, diseases, medications, and emotional states.

### The Science of Eye Color: From Birth to Adulthood and Beyond
* 👶 Eye color is not fully developed at birth, with melanocytes continuing to populate the iris and eyes often **darkening over the first few months of life**.
* 👴 Eye color can continue to change into adulthood, with a twin study showing that **10-15% of white participants' eyes darkened** between age 6 and adulthood.
* 👁 Age-related changes can also affect eye color, with conditions like **Arcus senilis** causing a **light blue or gray ring around the iris** in elderly individuals.
* - Various eye conditions, such as Horner's syndrome, Fuchs heterochromic iridocyclitis, and pigment dispersion syndrome, can lead to **changes in eye color**.
* 👓 Medications, including prostaglandins used to treat glaucoma, can cause eye color changes, with one study finding that latanoprost darkened the eyes of **5-23% of patients after 12 months**.
* 🦠 Diseases like vitiligo can affect eye color, with autoimmune destruction of melanocytes leading to **patchy or widespread pigment loss in the iris**.
* 🎭 Emotional states and brain trauma can also temporarily alter the appearance of eye color, with **fear causing more drastic pupil dilation** and brain trauma potentially **permanently affecting pupil size**.
* 👁 Advances in medical technology, such as iris implants for individuals with congenital aniridia, offer the potential for individuals to **choose their eye color**, although these procedures are still relatively new and come with **potential risks**.

You probably think you know the 
color of your eyes pretty well. After all, most of us see them staring 
back at us in the mirror every day. And while our bodies may 
change, eye color is permanent. Until it’s not. There are a shocking number of things that 
can make your baby blues not so blue anymore, or can make your brown-eyed 
girl need a new nickname. Here are just a few of them. First, let’s start by breaking 
down how the iris works. Your iris is the gatekeeper 
to light entering the eye. It contains the muscle to open and close the pupil 
so it regulates how much light gets in there. Irises also come in a 
spectrum of spectacular colors thanks to their cellular makeup. There are two layers of the iris. Within these layers, there’s a whole bunch of very important stuff that all helps you see. But the bits we want to focus on are the ones that have to do with eye color.

the melanocytes. Melanocytes are found in both layers of the iris. Two-thirds of all cells in the anterior layer, which is called the iris stroma, are melanocytes. So this layer is doing a lot of heavy lifting in giving your eyes their hue. And melanocytes aren’t just in your eyes. They make melanin all throughout your body. This is the same melanin that gives your skin and hair whatever color they’ve got. Melanin absorbs light, meaning it can’t be reflected back to be perceived by us. More melanin in a spot means more light is being absorbed there, and we see it as a darker color. So in brown eyes, there’s lots of melanin present and lots of light being absorbed. But lighter-colored eyes have less melanin, which means that the shorter wavelengths of light get reflected back off of collagen fibers. And then when someone else looks at those melanin-lacking eyes, their eyes pick up on that reflected light.

and that is how we see each other’s eye color. Melanin also comes in two forms: eumelanin, which is black or dark brown, and pheomelanin, which is light brown, yellow, or red. And different combinations of eumelanin and pheomelanin will affect the color of your eyes, kind of like mixing paint colors. For example, people with green eyes have more of that yellow-red pheomelanin. But not all eye colors are the result of melanin. If you’ve got albinism or another condition where you have little to no melanin, it’s the blood vessels in the retina reflecting back light that give a pink or reddish hue. There’s also a lot that can change in a complicated system like the eyeball, so let us talk about a few ways your eye color can change! [ INTRO MUSIC ] Although babies spend about 9 months developing in the womb,

when they come into the 
world, all fresh and squishy, they are not done cooking just yet. And it’s not just growing 
bones and developing brains that change over the coming months and years. The eye color can change, too. Many babies have lighter eyes at 
birth than they will as adults. The idea is that melanocytes in those baby blues are either not finished moving into place, or the cells that are there haven’t gotten around to 
specializing as melanocytes yet. Over the first few months of life, the iris is populated with 
those pigment-making cells and gets darker. For the most part, the eye color will settle by around six years old. But for some, it doesn’t end there. A twin study found that 10-15% 
of white participants’ eyes continued to darken between age 6 and adulthood. The fact that this happens in twins shows a pretty strong link between age-changing eye color and genetics, so your darkening eyes might 
even run in the family.

But there’s a twist! Not only can growing to adulthood 
cause your eyes to get darker, aging all the way to your golden years can eventually make your eyes lighter. Kind of. Arcus senilis is a build up of lipids that can form around the iris and give it a light blue or gray ring. A sort of eyeball halo, if you will. This usually happens in elderly people, and the new hue is usually benign. But they can sometimes be a sign 
of another underlying condition. So it’s not a bad idea to get them checked out. There are also plenty of 
not-so-great eye conditions that can change your eye color. There are a few that can also lead to loss of pigment and lighter eyes. Horner’s syndrome is caused 
by damage or disruption to certain nerves in the head and neck. That comes with a whole bunch 
of neurological symptoms, but it also causes your eyes 
to get lighter in color. It’s super noticeable in babies, but in adults,

it can be harder to notice because it happens so slowly. You might only spot it when you look at a photo from 20 years ago and think, “hey, were my eyes like, way darker back then?” Likewise, Fuchs heterochromic iridocyclitis causes inflammation of structures in the front of the eye, including the iris. And eventually, all that inflammation comes with a lightening of the eyes. And are you proud of me for saying, “Fuchs heterochromic iridocyclitis” correctly? Because I am. It’s not fully understood what causes this to happen, but studies have found that people with Fuch’s have fewer melanocytes and smaller melanin producing machinery. And finally, we have pigment dispersion syndrome. The name basically just means a loss of pigment, which causes your eyes to get lighter. But it's the mechanism of this particular change where things get really interesting. Some researchers have proposed

that pigment loss happens with this condition because the iris is just too big for the eye, which causes it to bow backwards. This backward bowing causes the tiny thread-like fibers that hold the eye's lens in place to come into contact with the iris, which they are not supposed to do. And when that happens, those threads can literally rub the pigment off. It can also cause some other not-great things like glaucoma. But fortunately, glaucoma treatments can help treat pigment dispersion syndrome, too. Now instead of pigment gain or loss, the next one is kinda like DIY eye jewelry. Kayser-Fleischer rings are brown or grayish rings that can form a little ring around the iris. They’re caused by deposition of excess copper in the cornea, which lays over the top of the iris. These rings are common in patients with Wilson’s disease, a genetic disorder which causes an error in copper metabolism in the body, but they can also be caused by other problems like liver disease.

On the plus side, as long as you treat the condition that caused them to appear, Keyser-Fleischer rings should go away. Another bummer of a disease that can change eye color is cancer. Yes, iris melanomas are a thing. They’re not super common, but they do happen. Just like a skin melanoma, iris melanoma is a cancer starting in the melanocytes. And just as on the skin, this can present on the iris as dark brownish spots. They can also cause you to start seeing more floaters, and can change the shape of your pupil. Most iris melanomas will not be visible, but if new dark spots appear on your iris, it’s probably time to book an appointment with your doctor. And not only can a cancer cause your eye color to change, treating cancers can cause it too. There’s a rare type of eye cancer found in young children called retinoblastoma that is super aggressive.

But there’s a new treatment for retinoblastoma, which involves injecting chemotherapy drugs into the vitreous humor, which is the jelly-like substance between your lens and retina, of the affected eye. This sounds terrible, but like… we're getting the cancer. And while that treatment seems to work pretty well, there are a couple case studies that suggest the treatment also resulted in that eye getting lighter, giving those kids permanent heterochromia and a hell of a story to tell. We’ve got more cool science to share. But first, let me tell you about another way to learn cool science: Brilliant. With Brilliant, you don’t even need to limit yourself to science. You can choose from thousands of lessons in computer science and math too! All on one interactive learning platform. You can learn artificial intelligence with the help of professionals at Microsoft and Google. And you can harness some of the most advanced tools of our time, like large language models. With Brilliant

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supporting this SciShow video! Now we’ve talked about a lot of weird diseases that can change your eye color, but there are some medications 
that can do this too. One of the most common is a medication group

called prostaglandins, which are used to treat glaucoma. Glaucoma is just a blanket 
term for a group of conditions that cause increased pressure in your eye, and over time, damage to the optic nerve. And prostaglandins are great 
at lowering that pressure, so they are great for treating glaucoma. And they are also known for a weird side effect – darkening people’s irises. One study found that the 
glaucoma medication latanoprost caused between 5 to 23% of patients’ eyes to get darker after 12 months of treatment. It’s probably still a good idea to take these medications either way. Just don’t be surprised if 
you notice a new eye shade in your reflection afterwards. We’ve talked about dark flecks 
and white rings on the iris, but how about patchwork eye color? Vitiligo is an autoimmune disorder where your immune system turns on your melanocytes and destroys them.

It’s usually more apparent when 
it’s happening in the skin, since it causes large patches 
of skin to become much lighter than they were before. But it can happen to melanocytes in your eyes too, which can look like patchy blue spots in the iris, or more widespread loss of pigment. This specific presentation of vitiligo is often associated with 
specific eye-related syndromes like Vogt-Koyanagi-Harada syndrome and Alezzandrini's syndrome but can also happen in the more 
general, full-body vitiligo. And this is probably the most temporary eye color 
swapping method on our list – but your eye color can look really different depending on your emotional state. Novelists might be taking some artistic liberty when they describe eyes becoming 
“dark and stormy” in anger but there really is something there. Not all eye color changes come down to the iris. The size of the pupil plays a role too. Your pupil dilates differently

when you are processing different emotions. One study found that fear can cause the pupil to dilate more drastically than feelings of happiness or neutrality, which would temporarily make your eyes look a different color as less of your iris is visible. And of course this isn't really an eye color change, but it is the illusion of one. Another illusory eye color change can come from trauma to the brain or eye. A nasty knock on the head can cause your pupil to get permanently stuck at full dilation. And, like we mentioned before, greater pupil size equals less visible iris and a whole different looking eye color. This can happen in both eyes but usually it’s just one. And if this ever happens to you, you're in good company, since a permanently blown pupil was also the cause of David Bowie’s famous mismatched eyes. Whether it also makes you a rock legend… less clear. Everything we’ve talked about so far that can change your eye color comes down mostly to a roll of the dice.

But what if you could choose your own adventure and actually select your eye color? It sounds like science fiction, but for some, this has become a reality. Congenital aniridia is a rare genetic eye disorder where you are born without a part of or all of your iris. As with trauma to the eye, this means that your pupil is larger and your eyes look darker. Without the pupil control, this of course leaves people with sensitivity to light and even lead to vision loss. But there’s a procedure that can help correct this - an iris implant! They are not FDA approved yet, but doctors can get exemptions to use them on compassionate grounds in the US, and they are available in some other countries. And the caution to approve them for wider scale use might be warranted. Because although iris implants might improve vision and reduce glare in individuals with aniridia, they might also cause some nasty complications like glaucoma. These prostheses are still pretty new.

so it’s up to each individual and their doctor to weigh the risks and benefits. So if you do have a condition where having a new iris could 
really help, technically, you could go for any color you want. Maybe throw some stripes on 
there and get funky with it. So now you know! There’s a lot that can happen 
to change your eye color. And while it may be jarring to see such a change, no matter what color they are, we think that beauty is in 
the eyes of the beholder. [outro]

11 Things That Can Change Your Eye Color

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Eye color is determined by the amount of melanin in the iris, with more melanin resulting in darker eyes and less melanin in lighter eyes.

The combination of eumelanin and pheomelanin in the iris can create different eye colors, similar to mixing paint.

In some cases, eye color can also be affected by conditions like albinism, which results in the blood vessels in the retina giving off a pink or reddish hue.

Eye color can change significantly from birth to adulthood, with the iris becoming darker in the first few months of life.

Genetic factors play a strong role in the evolution of eye color, with a potential for continued darkening into adulthood, and even lightening in old age.

Certain eye conditions and syndromes can also cause the eyes to lighten in color, indicating underlying health issues and a loss of pigment.

Pigment loss in the eye can be caused by pigment dispersion syndrome, which can also lead to glaucoma, but can be treated with glaucoma treatments.

Kayser-Fleischer rings, caused by excess copper deposition in the cornea, are common in Wilson's disease patients and can be resolved by treating the underlying condition.

Iris melanomas, although rare, can cause dark spots on the iris and vision changes, requiring a doctor's appointment if new spots appear.

Retinoblastoma, a rare eye cancer in children, can be treated with chemotherapy, which has been linked to causing permanent heterochromia in the affected eye.

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Medications for glaucoma can cause a change in eye color, and vitiligo can also affect the color of the eyes by destroying melanocytes.

Additionally, emotional states and pupil size can temporarily change the appearance of eye color.

Fear can cause the pupil to dilate, giving the illusion of a different eye color, while trauma can permanently change the eye color due to pupil dilation.

An iris implant procedure is available for people with congenital aniridia, allowing them to choose their eye color, but it comes with the risk of complications like glaucoma.