Arginine: Effects, Risks, and Cancer Concerns

Consuming arginine for muscle building is safe, but cancer patients should avoid it due to its potential mTOR protein activation.

### Arginine: Effects, Concerns, and Recommendations
* 💪 Arginine relaxes blood vessels, promotes blood circulation, lowers blood pressure, and helps with digestion. It also promotes muscle synthesis, making it **beneficial for exercise** when taken before working out.
* 🚫 Individuals with liver issues, such as cancer patients undergoing treatment or taking a break during treatment, should be cautious when consuming arginine due to its effects on the **mTOR protein**.
* 🎯 "mTOR is a protein that operates when there is an **excess of energy**, synthesizing more proteins and fats, **cleansing the body**, and **suppressing autophagy**."
* ⚖ It is crucial to maintain a balance between **AMPK, which promotes autophagy**, and **mTOR, which promotes anabolism**, as they interact with each other.
* For cancer patients or those on a break during cancer treatment, it is necessary to be cautious about consuming arginine, as it can **promote cell proliferation** and the **development of new blood vessels** that can cause cancer.
* 🔬 Preclinical and clinical data suggest potential issues related to **lung cancer, breast cancer, ovarian cancer, pancreatic cancer, prostate cancer, and other cancers**.
* ✅ For individuals who are not cancer patients, consuming arginine is generally safe and beneficial, especially for those who exercise. Blindly inhibiting mTOR or avoiding arginine altogether is **not recommended**. It is essential to consume it in **balance with other nutrients**.

I worked out so hard, so I should take arginine to build muscles, right? Hello, this is Yakdeulyak's pharmacist. Let's cheer first and get started. Fighting! Today's video is about arginine. Those who are like this, never take it. I will talk about those who should stop taking it immediately. Arginine is a very safe supplement with almost no side effects. However, there are people who should not take it. I will explain a bit deeper about why. First, let me briefly mention the general effects of arginine. Arginine relaxes blood vessels, promotes blood circulation, lowers blood pressure, and helps with digestion. It also promotes muscle synthesis, which helps with exercise when taken before working out.

If it is a supplement that can induce bulking up and also works in a cycle that detoxifies ammonia, the amino acid that functions in the liver is arginine. Generally known side effects may include gastrointestinal discomfort, mild allergies, and dizziness due to low blood pressure. Moreover, lysine deficiency-related shingles or inflammatory reactions may occur as absorption can lead to temporary elevation of liver enzymes. Therefore, I believe that individuals with liver issues, such as cancer patients undergoing treatment or taking a break during treatment, should be cautious when consuming arginine for vitality or energy enhancement purposes. The reason for this caution is mainly due to the metabolism of the mTOR protein.

When it comes to protein, what is m2? I briefly mentioned something called M-TOR when I was explaining about sirtuin saltwin before, and when I was explaining about autophagy, the process of cleaning our body, I mentioned M-TOR briefly. The factor that activates the M-TOR protein is arginine, that's right. Entor is the mechanistic target of rapamycin, the target substance of rapamycin. This means that m2 is the substance that rapamycin inhibits and was discovered. So, let's first find out what rapamycin is. In Korea, the prescription drug Synolis or Rapamenishi is prescribed, and this ingredient is used for immune suppression or anti-cancer purposes. It is an anti-cancer ingredient found in bacteria in the Eastern European soil.

In 1960, when it was first discovered and researched, it was found that the lifespan at the cellular level was extended. Furthermore, observing an extension of lifespan in mouse experiments made researchers wonder what exactly caused this substance to extend lifespan. Upon investigation, it was found that ultimately, this substance inhibits a protein called mTOR, which is involved in the process of rapamycin targeting. This substance is named mTOR. In the case of mTOR, when it is activated, we can infer that lifespan may be shortened, and diseases may develop. This is where the protein mTOR comes into play. Understanding a protein called m2 may be a bit difficult, so let me explain the opposite action more precisely with a protein I mentioned before, which is AMPK. When AMPK levels increase, mTOR levels decrease, and when mTOR levels increase, AMPK levels decrease, showing opposite actions towards each other.

APK is an enzyme that activates when our body lacks energy and the energy substance called AMP is high. So, when our body is in a state of low energy, that enzyme is activated. It works as an enzyme that prevents the breakdown of energy in our body, preventing the breakdown of proteins and fats. It promotes the production of energy by inhibiting the breakdown of energy due to the lack of energy. By burning energy, appetite increases, but as fat metabolism is stimulated, body fat decreases. As a result, autophagy is activated in our body, which can show anti-cancer and anti-inflammatory effects in the body, and by inducing consumption, it promotes the function of producing and metabolizing something in our body.

By synthesizing reproductive hormones, it promotes various metabolisms. Insulin resistance is reduced, blood pressure is lowered, and it has many beneficial effects. The enzyme that does this is called AMPK. The opposite of that is called mTOR. mTOR, on the contrary, operates when there is an excess of energy, when the stomach is full after eating a lot, or when there is little exercise. It is a protein that functions like this. mTOR, for example, stimulates digestion. When there is excess energy in our body, it synthesizes more proteins and fats. Also, due to the excess energy, it cleanses our body, suppresses autophagy, which prevents cancer, and reduces the organelles called lysosomes that break down within the cell. The organ that melts waste decreases, and as the muscles become stronger, cell replication increases a lot.

When it is converted into energy, a lot of this interaction occurs in the process, and it is known that if inflammation control is not well regulated during the process of cell production, cancer can be more likely to occur. It is known to be a bit more complicated in terms of signaling, but you can just think of it that way. When cells replicate a lot, if the inflammatory response is not well regulated and various antioxidant actions are not regulated, then the possibility of cancer occurrence increases. In fact, research is being conducted on an enzyme that blocks arginine as an anticancer treatment. There is data that about 20 something clinical trials are being conducted in phase 3 or higher. Blocking arginine to the extent that it can be used as an anticancer agent is now showing some beneficial effects on cancer patients. In summary, when the protein mTOR is activated, cell proliferation and the autophagy system are activated.

When suppressed, various inhibitions and somewhat fairy-tale-like stimulations can arise in the mind, leading to the possibility of developing emotions. In the case of cancer patients, one should be careful in that aspect. Activating a protein called mTOR is precisely what arginine does. It would be good to see it this way. Furthermore, arginine not only activates mTOR but also promotes the secretion and synthesis of nitric oxide, which expands blood vessels as mentioned earlier. It is said that when this happens, the newly formed blood vessels that can cause cancer can develop further. In cases of cancer, when arginine is not sufficient, cells with arginine-dependent deficiency may self-destruct. So, the probability of cancer occurrence decreases when there is enough arginine. Through these actions, arginine...

For cancer patients or those currently undergoing cancer treatment, and those on a break during their treatment, such as a leave of absence, it seems necessary to be cautious about consuming arginine. Particularly, based on the data I found, which mostly consists of preclinical cell experiments or animal experiments, there are data suggesting that various cancers such as lung cancer, breast cancer, ovarian cancer, and pancreatic cancer can mainly occur. Clinical trials show similar results, indicating potential issues related to prostate cancer, pancreatic cancer, and breast cancer. Therefore, it is advisable to be cautious. However, for those who are not cancer patients, there is absolutely no need to worry. Arginine is not necessarily bad. As I mentioned earlier, it is most important to maintain a balance between the protein AMPK, which promotes autophagy, and mTOR, which promotes anabolism, as they interact with each other. Therefore, blindly inhibiting mTOR is not necessary.

Not taking arginine blindly is not good. Therefore, it is not good to avoid consuming arginine altogether. So, consume it in balance. People who exercise like this, those who are not cancer patients, benefit a lot from consuming arginine, so there is no need to worry at all about consuming it. Especially, regarding concerns about cancer patients, it only applies to cancer patients. Therefore, saying that arginine is a big problem in causing cancer is really a speculation, and there is no data to support that. There are three substances that act as substrates activating protein with m2. The first is arginine, the second is glutamine, and the third is lysine. However, these substances create an anabolic effect and play a role in creating cells, but some people ask if consuming them can cause cancer or find it difficult.

Speculation and groundless claims, individuals who are not cancer patients, there is absolutely no data that consuming glutamine, lysine, or arginine causes cancer. So, don't worry, don't speculate too much, and keep this in mind as we strive for a healthier nutritional supplement lifestyle. Don't worry too much, I'm just mentioning this for your reference. Always, when cancer patients ask about arginine for their physical strength, I once mentioned it with care. Today's video talked about why people who consume arginine should not do so. If today's video was helpful, please like and subscribe. Thank you, bye. [MUSIC]

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The Effects of Arginine Supplementation and Who Should Avoid It

Arginine has various benefits such as promoting blood circulation and muscle synthesis, but it can cause side effects like gastrointestinal discomfort and dizziness.

Individuals with liver issues, especially cancer patients undergoing treatment, should be cautious when taking arginine due to its impact on the mTOR protein and liver enzymes.

Rapamycin, which is related to the mTOR protein, is a prescription drug used for immune suppression and anti-cancer purposes, further highlighting the potential risks of arginine for certain individuals.

The substance mTOR was discovered in 1960 to extend cellular lifespan and its inhibition is linked to lifespan extension and disease prevention.

mTOR's activation shortens lifespan and is associated with disease development, while the enzyme AMPK has the opposite effect, promoting energy production and metabolism.

AMPK activation leads to increased energy production, decreased body fat, and the activation of autophagy, offering anti-cancer and anti-inflammatory effects.

The Role of AMPK and mTOR in Metabolism and Cell Function

Synthesizing reproductive hormones, AMPK reduces insulin resistance and lowers blood pressure, offering various beneficial effects.

On the other hand, mTOR operates in times of energy excess, stimulating digestion and synthesizing proteins and fats.

mTOR also suppresses autophagy and increases cell replication, potentially impacting cancer development.

Research on blocking arginine, an enzyme related to mTOR, is showing promise as an anticancer treatment in clinical trials.

In summary, mTOR activation promotes cell proliferation and impacts the autophagy system.

The Impact of Arginine on Cancer Development

Arginine activates the protein mTOR and promotes the synthesis of nitric oxide, which can further develop blood vessels and potentially cancer.

In cancer patients, a deficiency of arginine can lead to a decrease in cancer occurrence, but for non-cancer patients, there is no need to worry about consuming arginine.

It is important to maintain a balance between AMPK and mTOR, as blindly inhibiting mTOR is not necessary, especially for those who are not cancer patients.

The Role of Arginine in Nutrition and Exercise

Avoiding arginine consumption altogether is not recommended, especially for non-cancer patients and those who exercise.

Speculations about arginine causing cancer lack supporting data, and it is considered safe for non-cancer patients.

Arginine, along with glutamine and lysine, plays a role in cell creation and has an anabolic effect, but there is no evidence that they cause cancer.

It is important to consume arginine in balance and not worry excessively, as it can benefit physical strength and overall nutritional supplement lifestyle.