poe 3.25 Guide to Sanctum: Prioritizing Loot and Avoiding Afflictions

In Sanctum, prioritize damage Boons, avoid bad Afflictions like Golden Smoke, and seek scrying Crystal for loot vision.

### Guide to Maximizing Gains in Sanctum
Sanctum is the best early game money printer due to its raw currency rewards. When choosing boons and afflictions, prioritize damage-boosting boons and the scrying crystal for room visibility. Avoid afflictions like Golden Smoke and Black Smoke, which limit your ability to find divine rooms. Major boons are not always better than minor boons, so focus on the ones that enhance your damage. When considering affliction trades, assess their impact on your run and consider using inspiration to mitigate major afflictions. Be cautious with the cup purse affliction, as it can limit your ability to gain orus coins for buying rewards. Always keep in mind the potential consequences of affliction trades to avoid getting locked out of buying rewards.

### Navigating the Sanctum: A Guide to Room Prioritization
Prioritize collecting coins early to buy Boons later, making the overall run easier. Usher packed rooms should be a priority, offering three trade deals and a random reward. When making trade deals, consider the potential benefits and downsides carefully to optimize the run.

### Making Strategic Choices in a Video Game Run
Choosing boons and afflictions can impact the difficulty and potential success of the game run. Prioritizing currency and character upgrades is crucial for long-term progress in the game. Making strategic decisions based on the character's abilities and the potential risks can ultimately affect the outcome of the run.

### Navigating the Game Room and Making Strategic Choices
Sprinting through the fire trap room can result in resolve damage, so it's advised to proceed with caution. It's recommended to eliminate every guard before dealing with a particular persistent guard to avoid wasting time. Choosing the "lose 25% resolve" option can be beneficial if having only one resolve, as it allows for a free removal. It's generally advisable to avoid taking the "gain random affliction" option, as it can negatively impact the run, and to prioritize removing afflictions that cause chip damage. The "Radiant Fountain" room is a high priority for gaining inspiration, a free Boon, and affliction removal, while in the boss floor fight, it's suggested to prioritize targeting a specific enemy to make the battle more manageable. Sprinting through the "Gauntlet" rooms and prioritizing certain actions can make the run easier, while being mindful of the different room types and strategic choices.

### Strategies for Navigating Sanctum Floors
Navigating trap guard rooms on different floors requires specific strategies, with floor four having the most challenging rooms to avoid. Prioritizing valuable items over less useful ones can help optimize the run. Sprint to the end rooms and curse packs are priority rooms for better loot and a chance to roll a divine, especially on the higher floors. It's important to make the most of resolve trades for benefits, especially in challenging runs.

### Risking It All for Loot: A Gamer's Dilemma
The speaker is taking multiple risks in the game to obtain loot, despite the potential negative consequences for their character's abilities. They are willing to gamble on various in-game options, prioritizing the chance for valuable items over guaranteed benefits. The player emphasizes the importance of taking risks for loot, believing that the potential rewards outweigh the possible setbacks.

### Navigating a Gaming Level with Expert Tips
Take it slow or sprint through the level depending on your familiarity with the patterns and guards. Utilize specific strategies to minimize damage and resolve loss while navigating the rooms. Make smart choices to maximize loot and increase your chances of success in the game.

### Tips for Navigating the Sanctum Run in Path of Exile
Sanctum runs can provide a mix of chaos and other currencies, with the potential for valuable divines and unique relics. It's important to maintain high chaos resistance to avoid being one-shotted by the chaos damage from the boss. Paying attention to mechanics and optimizing gameplay can maximize the value of each sanctum run, despite the potential for variation in returns.

### Sanctum Guide: Boons, Afflictions, and Run Strategy
* 💰 " Raw currency is King, and **sanctum is the king of raw currency early**.
* 🏆  Prioritize **Boons over Afflictions**, focusing on **damage** and **scrying Crystal for room visibility**.
* 🚫  Avoid major Afflictions like **Golden Smoke**, which hinder **divine room finding**, and choose minor Afflictions carefully based on your character's **strengths**.
* 💼  Consider trading **resolve for inspiration** in curse packs, especially if you have **one Max resolve**.
* 🔮 " Every single piece of currency you get will make it easier for you to **complete more and more runs**.
* 🏃‍♂️  Sprint through gauntlet rooms to **minimize damage from fire traps**.
* 🧙‍♂️ " Put down your **two benit friends** on your enemy and then just **hop around, just hop around**.
* 💡 " If you're playing my league starter, which is **penance brand of dissipation**, do what I'm doing.

### Sanctum of Domination: Complete Walkthrough and Strategy Guide
* 🏰  The player navigates through various rooms on different floors of the Sanctum, encountering **different challenges and rewards**.
* 🗺️  Each floor has different types of rooms, such as the **Trap Guard room** on floor one and the **Desecrated Crips** on floor four.
* 🏆  The player strategically chooses between different options, like taking a curse pack for a chance at a **Divine** instead of guaranteed **chaos**.
* 💰  The main goal is to **collect loot**, with the expectation of getting at least **one Divine** and a certain amount of **chaos orbs per run**.
* 🗡️  Combat strategies include using the "**circle strategy**," where the player moves in a **circular pattern** while placing **brands on enemies**.
* 🧭  The player carefully navigates trap rooms, using specific techniques to **avoid damage**, such as **jumping through the laser beams**.
* 🎯  The final boss fight against Lysia is showcased, with tips on **positioning and avoiding her powerful attacks**.
* 💡  The guide emphasizes the importance of **smart decision-making**, **risk-taking for potential rewards**, and **optimizing loot collection** in Sanctum runs.

In Path of Exile: Settlers of Kalguur, help Kalguuran pioneers to build the town of Kingsmarch and establish trade between Wraeclast and their homeland.

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How To Sanctum? Walkthrough + Basics

How To Sanctum? Walkthrough + Basics